ArticleJournal of biomedical optics2015
Probing differentiation in cancer cell lines by single-cell micro-Raman spectroscopy.
Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Automated Label-Free Classification of Circulating Tumor Cells and White Blood Cells Using Hyperspectral Imaging and Deep Learning on Microfluidic SACA Chip System.Micromachines · 2026Article
- Raman spectroscopy for viral diagnostics.Biophysical reviews · 2023Review
- Micro-Raman spectroscopy study of optically trapped erythrocytes in malaria, dengue and leptospirosis infections.Frontiers in medicine · 2022Article
- Human red blood cell behaviour in hydroxyethyl starch: probed by single cell spectroscopy.RSC advances · 2020Article
- Article
- Micro-Raman Spectroscopy Analysis of Optically Trapped Erythrocytes in Jaundice.Frontiers in physiology · 2020Article
- Raman Spectroscopy for Rapid Evaluation of Surgical Margins during Breast Cancer Lumpectomy.Scientific reports · 2019Article
- Normal saline-induced deoxygenation of red blood cells probed by optical tweezers combined with the micro-Raman technique.RSC advances · 2019Article
- Label-free classification of neurons and glia in neural stem cell cultures using a hyperspectral imaging microscopy combined with machine learning.Scientific reports · 2019Article
- Raman micro-spectroscopy for accurate identification of primary human bronchial epithelial cells.Scientific reports · 2018Article
- Raman microscopy of bladder cancer cells expressing green fluorescent protein.Journal of biomedical optics · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-cell micro-Raman spectroscopy has been applied to explore cell differentiation in single, live, and malignant cells from two tumor cell lines. The spectra of differentiated cells exhibit substantial enhancement primarily in the intensities of protein peaks with concomitant decrease in intensities of O−P−O asymmetric stretching peaks in DNA/RNA. Principal component analyses show that the spectral score of differentiated cells tends to asymptotically approach that of spectra obtained from normal neural stem cells/progenitors. This lends credence to the notion that the observed spectral changes are specific to differentiation, since upon differentiation, malignant cells become less malignant and tend toward benignity.
Indexed as
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26244913What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.