Evidence map›Paper›PMID 26259960›Full record

ArticleThe international journal of neuropsychopharmacology2015

Magnetoencephalographic Correlates of Emotional Processing in Major Depression Before and After Pharmacological Treatment.

Katharina Domschke, Peter Zwanzger, Maimu A Rehbein, Christian Steinberg, Kathrin Knoke, Christian Dobel, Isabelle Klinkenberg, Harald Kugel, Anette Kersting, Volker Arolt and 2 more

Erratum issuedAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Assessing and conceptualizing frontal EEG asymmetry: An updated primer on recording, processing, analyzing, and interpreting frontal alpha asymmetry.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Katharina DomschkeDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Peter ZwanzgerDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Maimu A RehbeinDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Christian SteinbergDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Kathrin KnokeDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Christian DobelDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Isabelle KlinkenbergDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Harald KugelDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Anette KerstingDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Volker AroltDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Christo PantevDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting).
Markus JunghoferDepartment of Psychiatry, University of Muenster, Germany (Drs Domschke, Zwanzger, Knoke, and Arolt); Department of Psychiatry, University of Wuerzburg, Germany (Dr Domschke); Institute of Biomagnetism and Biosignal Analysis, University of Muenster, Germany (Ms Rehbein and Klinkenberg, Drs Steinberg, Dobel, Pantev, and Junghofer); Department of Radiology, University of Muenster, Germany (Dr Kugel); Department of Psychosomatic Medicine, University of Leipzig, Germany (Dr Kersting). markus.junghoefer@uni-muenster.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn major depressive disorder (MDD), electrophysiological and imaging studies suggest reduced neural activity in the parietal and dorsolateral prefrontal cortex regions. In the present study, neural correlates of emotional processing in MDD were analyzed for the first time in a pre-/post-treatment design by means of magnetoencephalography (MEG), allowing for detecting temporal dynamics of brain activation.

methodsTwenty-five medication-free Caucasian in-patients with MDD and 25 matched controls underwent a baseline MEG session with passive viewing of pleasant, unpleasant, and neutral pictures. Fifteen patients were followed-up with a second MEG session after 4 weeks of antidepressant monopharmacotherapy with mirtazapine. The corresponding controls received no intervention between the measurements. The clinical course of depression was assessed using the Hamilton Depression scale.

resultsPrior to treatment, an overall neocortical hypoactivation during emotional processing, particularly at the parietal regions and areas at the right temporoparietal junction, as well as abnormal valence-specific reactions at the right parietal and bilateral dorsolateral prefrontal cortex (dlPFC) regions were observed in patients compared to controls. These effects occurred <150 ms, suggesting dysfunctional processing of emotional stimuli at a preconscious level. Successful antidepressant treatment resulted in a normalization of the hypoactivation at the right parietal and right temporoparietal regions. Accordingly, both dlPFC regions revealed an increase of activity after therapy.

conclusionsThe present study provides neurophysiological evidence for dysfunctional emotional processing in a fronto-parieto-temporal network, possibly contributing to the pathogenesis of MDD. These activation patterns might have the potential to serve as biomarkers of treatment success.

Indexed as

AdultAntidepressive AgentsCase-Control StudiesEmotionsFemaleFollow-Up StudiesHumansMagnetoencephalographyMajor Depressive DisorderMaleMiddle AgedTreatment OutcomeAntidepressive AgentsDorsolateral prefrontal cortexEEGIAPSMDDMEGparietal hypoactivationtemporoparietal junction

Identifiers

PMID26259960
PMCPMC4772824

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.