Evidence map›Paper›PMID 26260349›Full record

SynthesisBMJ open2015

A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses.

Katherine Esposito, Maria Ida Maiorino, Giuseppe Bellastella, Paolo Chiodini, Demosthenes Panagiotakos, Dario Giugliano

2 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 218 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
218citing papers in PubMed, 20 pooled it
25.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03104712 nacompletednot on this mapstarted 2017, after this paper: background citation

The Importance of Glycemic Index on Postprandial Glycemia and Insulinemia in the Context of the Addition of Fat to Carbohydrate Foods: A Randomized Controlled Trial on Spaghetti Versus Rice as Mixed Meals

TypeinterventionalSponsorUniversity of ParmaRan2017 to 2018Enrolled13ConditionsDietary ModificationArmsGlucose #1, Glucose #2, Glucose #3, Spaghetti, Rice
NCT06601478 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Development and Implementation of a Tool for the Evaluation and Monitorization of Mediterranean Lifestyle at Clinical Settings: MEDLIFE Index, a Proof of Concept Study

TypeinterventionalSponsorUniversidad Autonoma de MadridRan2024 to 2026Enrolled80ConditionsLifestyleArmsThe MedLIFE app
3 · Its place in the literature

Who cites it

218 citing papers in PubMed, 20 syntheses or guidelines pooled it, 485 citations in OpenAlex.

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158 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Katherine EspositoDiabetes Unit, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy.
Maria Ida MaiorinoDivision of Endocrinology and Metabolic Diseases, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
Giuseppe BellastellaDivision of Endocrinology and Metabolic Diseases, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
Paolo ChiodiniMedical Statistics Unit, Second University of Naples, Naples, Italy.
Demosthenes PanagiotakosDepartment of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Dario GiuglianoDivision of Endocrinology and Metabolic Diseases, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Naples, Italy.
University of Campania "Luigi Vanvitelli" · ITHarokopio University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo summarise the evidence about the efficacy of a Mediterranean diet on the management of type 2 diabetes and prediabetic states.

designA systematic review of all meta-analyses and randomised controlled trials (RCTs) that compared the Mediterranean diet with a control diet on the treatment of type 2 diabetes and prediabetic states was conducted. Electronic searches were carried out up to January 2015. Trials were included for meta-analyses if they had a control group treated with another diet, if they were of sufficient duration (at least 6 months), and if they had at least 30 participants in each arm. A random-effect model was used to pool data.

participantsAdults with or at risk for type 2 diabetes.

interventionsDietary patterns that described themselves as using a 'Mediterranean' dietary pattern. OUTCOME MEASURES: The outcomes were glycaemic control, cardiovascular risk factors and remission from the metabolic syndrome.

resultsFrom 2824 studies, 8 meta-analyses and 5 RCTs were eligible. A 'de novo' meta-analysis of 3 long-term (>6 months) RCTs of the Mediterranean diet and glycaemic control of diabetes favoured the Mediterranean diet as compared with lower fat diets. Another 'de novo' meta-analysis of two long-term RCTs showed a 49% increased probability of remission from the metabolic syndrome. 5 meta-analyses showed a favourable effect of the Mediterranean diet, as compared with other diets, on body weight, total cholesterol and high-density lipoprotein cholesterol. 2 meta-analyses demonstrated that higher adherence to the Mediterranean diet reduced the risk of future diabetes by 19-23%.

conclusionsThe Mediterranean diet was associated with better glycaemic control and cardiovascular risk factors than control diets, including a lower fat diet, suggesting that it is suitable for the overall management of type 2 diabetes.

Indexed as

Diet, Fat-RestrictedDiet, MediterraneanAdultBlood GlucoseCardiovascular DiseasesCholesterol, HDLDiabetes Mellitus, Type 2HumansRandomized Controlled Trials as TopicRisk FactorsWeight LossBlood GlucoseCholesterol, HDLDIABETES & ENDOCRINOLOGYNUTRITION & DIETETICSPREVENTIVE MEDICINE

Identifiers

PMID26260349
PMCPMC4538272
OpenAlexW1860042119

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.