Evidence map›Paper›PMID 26312625›Full record

ArticleGenes and immunity2015

Association of 4p14 TLR locus with antibodies to Helicobacter pylori.

H Sung, M C Camargo, K Yu, S J Weinstein, D R Morgan, D Albanes, C S Rabkin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. miR-574-5p in epigenetic regulation and Toll-like receptor signaling.Cell communication and signaling : CCS · 2024
    Review
  3. Article
  4. Article
  5. Reply to Pachathundikandi and Backert.The Journal of infectious diseases · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

H SungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
M C CamargoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
K YuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
S J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
D R MorganDivision of Gastroenterology, Vanderbilt University, Nashville, TN, USA.
D AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
C S RabkinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
National Cancer Institute · USDivision of Cancer Epidemiology and GeneticsVanderbilt University · US

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Project 3 - Molecular Signatures of Gastric Carcinogenesis in the Host Response to H. pyloriP01CA028842 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 1985 to 2019
$15.8M
Molecular mechanisms of infection-related cancerZIACP010212 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ENGELS, ERIC A · 2010 to 2025
$4.6M
Targeted chemoprevention of gastric carcinogenesis in high risk populationsR01CA190612 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, DOUGLAS, WILSON, KEITH T. · 2014 to 2018
$3.0M
U S-FINLAND STUDIES OF NUTRITION AND CANCERN01CN045165 · CN · NATIONAL PUBLIC HEALTH INSTITUTE · PI HEINONEN, O · 1985 to 1996
–
CCR NIH HHS N01 RC037004CCR NIH HHS N01-RC-45035Intramural NIH HHS ZIA CP010212NCI NIH HHS HHSN261201000006CNCI NIH HHS N01 CN045165NCI NIH HHS P01 CA028842NCI NIH HHS R01 CA190612NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

A genome-wide association study among Europeans related polymorphisms of the Toll-like receptor (TLR) locus at 4p14 and the Fcγ receptor 2a locus at 1q23.3 to Helicobacter pylori serologic status. We replicated associations of 4p14 but not 1q23.3 with anti-Helicobacter pylori antibodies in 1402 Finnish males. Importantly, our analysis clarified that the phenotype affected by 4p14 is quantitative level of these antibodies rather than association with seropositivity per se. In addition, we annotated variants at 4p14 as expression quantitative trait loci (eQTL) associated with TLR6/10 and FAM114A1. Our findings suggest that 4p14 polymorphisms are linked to host immune response to H. pylori infection but not to its acquisition.

Indexed as

Quantitative Trait LociAntibodies, BacterialFinlandGenome-Wide Association StudyHelicobacter InfectionsHelicobacter pyloriHumansMalePolymorphism, GeneticToll-Like Receptor 10Toll-Like Receptor 6Antibodies, BacterialTLR10 protein, humanTLR6 protein, humanToll-Like Receptor 10Toll-Like Receptor 6

Identifiers

PMID26312625
PMCPMC4670272
OpenAlexW2343598166

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.