Evidence map›Paper›PMID 26315843›Full record

ArticleInternational journal of obesity (2005)2016

Changes in inflammation, oxidative stress and adipokines following bariatric surgery among adolescents with severe obesity.

A S Kelly, J R Ryder, K L Marlatt, K D Rudser, T Jenkins, T H Inge

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00474318 (Teen-Longitudinal Assessment of Bariatric Surgery), which is not on this map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00474318 completednot on this map

Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research Project

TypeobservationalSponsorAnn & Robert H Lurie Children's Hospital of ChicagoRan2007 to 2024Enrolled250ConditionsObesity
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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  17. Management of the pediatric patient with asthma and obesity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

A S KellyDepartment of Pediatrics, University of Minnesota Medical School and University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
J R RyderDepartment of Pediatrics, University of Minnesota Medical School and University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
K L MarlattDepartment of Pediatrics, University of Minnesota Medical School and University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
K D RudserDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
T JenkinsCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
T H IngeCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USUniversity of Minnesota · USMinnesota Department of Health · USUniversity of Minnesota Medical Center · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · UNIVERSITY OF COLORADO DENVER · 1995 to 2025
$7.7M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · CINCINNATI CHILDRENS HOSP MED CTR · 2025 to 2025
$1.2M
Adolescent Gastric By-Pass and Diabetic PrecursorsR03DK068228 · CHILDREN'S HOSPITAL MED CTR (CINCINNATI) · 2005 to 2005
$149k
NCATS NIH HHS 8 UL1 TR000077NCATS NIH HHS 8 UL1TR000077NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1TR000114NCATS NIH HHS UL1 TR001425NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R03 DK068228NIDDK NIH HHS R03DK068228NIDDK NIH HHS T32 DK083250NIDDK NIH HHS T32-DK083250NIDDK NIH HHS U01 DK072493NIDDK NIH HHS UM1 DK072493
6 · The paper itself

Abstract

BACKGROUND/

objectivesInflammation, oxidative stress and dysregulation of adipokines are thought to be pathophysiological mechanisms linking obesity to the development of insulin resistance and atherosclerosis. In adults, bariatric surgery reduces inflammation and oxidative stress, and beneficially changes the levels of several adipokines, but little is known about the postsurgical changes among adolescents. SUBJECTS/

methodsIn two separate longitudinal cohorts we evaluated change from baseline of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemo-attractant protein-1 (MCP-1), oxidized low-density lipoprotein cholesterol (oxLDL), adiponectin, leptin and resistin up to 12 months following elective laparoscopic Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) surgery in adolescents with severe obesity.

resultsIn cohort 1, which consisted of 39 adolescents (mean age 16.5±1.6 years; 29 females) undergoing either RYGB or VSG, IL-6 (baseline: 2.3±3.4 pg ml(-1) vs 12 months: 0.8±0.6 pg ml(-1), P<0.01), leptin (baseline: 178±224 ng ml(-1) vs 12 months: 41.4±31.9 ng ml(-1), P<0.001) and oxLDL (baseline: 41.6±11.6 U l(-1) vs 12 months: 35.5±11.1 U l(-1), P=0.001) significantly decreased and adiponectin significantly increased (baseline: 5.4±2.4 μg ml(-1) vs 12 months: 13.5±8.9 μg ml(-1), P<0.001). In cohort 2, which consisted of 13 adolescents (mean age 16.5±1.6 years; 10 females) undergoing RYGB, results were similar: IL-6 (baseline: 1.7±0.9 pg ml(-1) vs 12 months: 0.4±0.9 pg ml(-1), P<0.05) and leptin (baseline: 92.9±31.3 ng ml(-1) vs 12 months: 37.3±33.4 ng ml(-1), P<0.001) significantly decreased and adiponectin significantly increased (baseline: 6.1±2.9 μg ml(-1) vs 12 months: 15.4±8.0 μg ml(-1), P<0.001). When the cohorts were combined to evaluate changes at 12 months, oxLDL also significantly decreased (baseline: 39.8±16.7 U l(-1) vs 12 months: 32.7±11.9 U l(-1), P=0.03).

conclusionsBariatric surgery produced robust improvements in markers of inflammation, oxidative stress and several adipokines among adolescents with severe obesity, suggesting potential reductions in risk for type 2 diabetes and cardiovascular disease.

Indexed as

Gastric BypassWeight LossAdipokinesAdiponectinAdolescentAtherosclerosisBiomarkersFemaleHumansInflammationInsulin ResistanceInterleukin-6Lipoproteins, LDLMaleObesity, MorbidOxidative StressAdipokinesAdiponectinADIPOQ protein, humanBiomarkersIL6 protein, humanInterleukin-6Lipoproteins, LDLTumor Necrosis Factor-alpha

Identifiers

PMID26315843
PMCPMC5546415
OpenAlexW1191564590

What Socratic holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.