Evidence map›Paper›PMID 26318600›Full record

ArticleBasic research in cardiology2015

Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakes.

Ioanna Andreadou, Efstathios K Iliodromitis, Csaba Szabo, Andreas Papapetropoulos

Open access · bronzeAbstract readEditorial
In one paragraph

Article in Basic research in cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Evidence for the Benefits of Melatonin in Cardiovascular Disease.Frontiers in cardiovascular medicine · 2022
    Review
  3. Trends in HAntioxidants (Basel, Switzerland) · 2021
    Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Ioanna AndreadouFaculty of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 15771, Athens, Greece.
Efstathios K Iliodromitis
Csaba Szabo
Andreas Papapetropoulos
National and Kapodistrian University of Athens · GRThe University of Texas Medical Branch at Galveston · USUniversity General Hospital Attikon · GR

Funding

Regulation of cellular bioenergetics by hydrogen sulfideR01GM107846 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SZABO, CSABA · 2014 to 2017
$1.2M
NIGMS NIH HHS R01 GM107846
6 · The paper itself

Abstract

Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dependent protein kinase can lie both downstream and upstream of H2S. The current literature on this topic is reviewed and data from recent studies are integrated to propose a unifying model.

Indexed as

AnimalsCyclic GMP-Dependent Protein KinasesHumansHydrogen SulfideMyocardial Reperfusion InjurySignal TransductionCyclic GMP-Dependent Protein KinasesHydrogen Sulfide

Identifiers

PMID26318600
PMCPMC4667708
OpenAlexW2127834679

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.