Evidence map›Paper›PMID 26324180›Full record

Trial reportDiabetes2016

Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults.

Matthew L Johnson, Klaus Distelmaier, Ian R Lanza, Brian A Irving, Matthew M Robinson, Adam R Konopka, Gerald I Shulman, K Sreekumaran Nair

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.

  1. Histone deacetylase-mediated regulation of endolysosomal pH.The Journal of biological chemistry · 2018
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Matthew L JohnsonDivision of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN.
Klaus DistelmaierDivision of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN.
Ian R LanzaDivision of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN.
Brian A IrvingDivision of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN.
Matthew M RobinsonDivision of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN.
Adam R KonopkaDivision of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN.
Gerald I ShulmanHoward Hughes Medical Institute and the Departments of Medicine and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT.
K Sreekumaran NairDivision of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN nair@mayo.edu.
Mayo Clinic · USYale University · US

Funding

OBESITYP30DK050456 · UNIVERSITY OF MINNESOTA TWIN CITIES · 1995 to 2005
$5.4M
MULTIDISCRIPLINARY TRAINING IN DIGESTIVE DISEASEST32DK007198 · NIDDK · MAYO CLINIC ROCHESTER · 1986 to 2025
$4.0M
DIABETES AND METABOLISMT32DK007352 · MAYO CLINIC ROCHESTER · 1986 to 2025
$2.5M
NMR STUDIES OF GLYCOGEN METABOLISM IN HUMANSR01DK049230 · YALE UNIVERSITY · 1995 to 2004
$2.5M
IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONESR01DK041973 · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · 1989 to 2005
$2.2M
Molecular Mechanisms of Portal HypertensionR01DK059615 · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · 2002 to 2005
$939k
Howard Hughes Medical InstituteNCATS NIH HHS KL2 TR000136NCATS NIH HHS KL2-TR-000136-07NCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1-TR-000135NCRR NIH HHS KL2 RR024151NCRR NIH HHS KL2-RR-024151NIDDK NIH HHS DK-50456NIDDK NIH HHS P30 DK050456NIDDK NIH HHS R01 DK041973NIDDK NIH HHS R01 DK049230NIDDK NIH HHS R01 DK059615NIDDK NIH HHS R01-DK-41973NIDDK NIH HHS R01-DK-49230NIDDK NIH HHS R24 DK090963NIDDK NIH HHS R24-DK-090963NIDDK NIH HHS R56 DK041973NIDDK NIH HHS T32 DK007198NIDDK NIH HHS T32-DK-007198NIDDK NIH HHS T32 DK007352NIDDK NIH HHS T32-DK-007352NIDDK NIH HHS U24 DK100469NIDDK NIH HHS U24-DK-100469
6 · The paper itself

Abstract

Caloric restriction (CR) improves insulin sensitivity and reduces the incidence of diabetes in obese individuals. The underlying mechanisms whereby CR improves insulin sensitivity are not clear. We evaluated the effect of 16 weeks of CR on whole-body insulin sensitivity by pancreatic clamp before and after CR in 11 obese participants (BMI = 35 kg/m(2)) compared with 9 matched control subjects (BMI = 34 kg/m(2)). Compared with the control subjects, CR increased the glucose infusion rate needed to maintain euglycemia during hyperinsulinemia, indicating enhancement of peripheral insulin sensitivity. This improvement in insulin sensitivity was not accompanied by changes in skeletal muscle mitochondrial oxidative capacity or oxidant emissions, nor were there changes in skeletal muscle ceramide, diacylglycerol, or amino acid metabolite levels. However, CR lowered insulin-stimulated thioredoxin-interacting protein (TXNIP) levels and enhanced nonoxidative glucose disposal. These results support a role for TXNIP in mediating the improvement in peripheral insulin sensitivity after CR.

Indexed as

Caloric RestrictionInsulin ResistanceSedentary BehaviorAmino AcidsBlood GlucoseBlotting, WesternCalorimetry, IndirectCarrier ProteinsCase-Control StudiesCeramidesDiglyceridesEnergy MetabolismFemaleGlucose Clamp TechniqueHumansHydrogen PeroxideAmino AcidsBlood GlucoseCarrier ProteinsCeramidesDiglyceridesHydrogen PeroxideTXNIP protein, human

Identifiers

PMID26324180
PMCPMC4686951
OpenAlexW2210293160

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.