Evidence map›Paper›PMID 26332887›Full record

ReviewThe Journal of physiology2016

Regulation of skeletal muscle blood flow during exercise in ageing humans.

Christopher M Hearon, Frank A Dinenno

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

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  9. Impaired modulation of postjunctional αThe Journal of physiology · 2018
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher M HearonHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, 80523, USA.
Frank A DinennoHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, 80523, USA.
Colorado State University · US

Funding

Exercise Hyperemia in HumansR01HL119337 · NHLBI · MAYO CLINIC ROCHESTER · PI DINENNO, FRANK A, JOYNER, MICHAEL J · 2014 to 2017
$3.0M
Aging, Sleep Apnea, & Vascular Control During Systemic HypoxiaR01HL095573 · NHLBI · COLORADO STATE UNIVERSITY · PI DINENNO, FRANK A · 2010 to 2014
$1.8M
Aging, Endothelial Dysfunction, and ATP-mediated Vasodilation in HumansR21HL087952 · NHLBI · COLORADO STATE UNIVERSITY · PI DINENNO, FRANK A · 2007 to 2008
$404k
Role of circulating ATP and smooth muscle cell hyperpolarization in vascular contR21HL102720 · NHLBI · COLORADO STATE UNIVERSITY · PI DINENNO, FRANK A · 2010 to 2011
$393k
NHLBI NIH HHS HL087952NHLBI NIH HHS HL095573NHLBI NIH HHS HL102720NHLBI NIH HHS HL119337NHLBI NIH HHS R01 HL119337
6 · The paper itself

Abstract

The regulation of skeletal muscle blood flow and oxygen delivery to contracting skeletal muscle is complex and involves the mechanical effects of muscle contraction; local metabolic, red blood cell and endothelium-derived substances; and the sympathetic nervous system (SNS). With advancing age in humans, skeletal muscle blood flow is typically reduced during dynamic exercise and this is due to a lower vascular conductance, which could ultimately contribute to age-associated reductions in aerobic exercise capacity, a primary predictor of mortality in both healthy and diseased ageing populations. Recent findings have highlighted the contribution of endothelium-derived substances to blood flow control in contracting muscle of older adults. With advancing age, impaired nitric oxide availability due to scavenging by reactive oxygen species, in conjunction with elevated vasoconstrictor signalling via endothelin-1, reduces the local vasodilatory response to muscle contraction. Additionally, ageing impairs the ability of contracting skeletal muscle to blunt sympathetic vasoconstriction (i.e. 'functional sympatholysis'), which is critical for the proper regulation of tissue blood flow distribution and oxygen delivery, and could further reduce skeletal muscle perfusion during high intensity and/or large muscle mass exercise in older adults. We propose that initiation of endothelium-dependent hyperpolarization is the underlying signalling event necessary to properly modulate sympathetic vasoconstriction in contracting muscle, and that age-associated impairments in red blood cell adenosine triphosphate release and stimulation of endothelium-dependent vasodilatation may explain impairments in both local vasodilatation and functional sympatholysis with advancing age in humans.

Indexed as

ExerciseMicrocirculationAgingEndothelium, VascularHumansMuscle, SkeletalNitric OxideSympathetic Nervous SystemVasodilationNitric Oxide

Identifiers

PMID26332887
PMCPMC4933119
OpenAlexW1905945537

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.