Evidence map›Paper›PMID 26346855›Full record

ArticleCase reports in radiology2015

Nonstenotic Culprit Plaque: The Utility of High-Resolution Vessel Wall MRI of Intracranial Vessels after Ischemic Stroke.

Adam de Havenon, Chun Yuan, David Tirschwell, Thomas Hatsukami, Yoshimi Anzai, Kyra Becker, Ali Sultan-Qurraie, Mahmud Mossa-Basha

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Case reports in radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03507374 early_phase1terminatedstarted 2018, after this paper: background citation

PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis

Ran2018Enrolled20Registered outcomes5Posted comparisons0ConditionsIntracranial Atherosclerosis, Intraplaque Hemorrhage, StrokeArmsAlirocumab, Placebo
Open the trial in the graph
NCT05907629 recruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

TypeobservationalSponsorYale UniversityRan2024 to 2029Enrolled300ConditionsStroke, Intracranial Atherosclerotic Stenosis (ICAS)ArmsMRI
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Multimodal imaging approach for the diagnosis of intracranial atherosclerotic disease (ICAD): Basic principles, current and future perspectives.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Review
  3. Vessel Wall Imaging in Cryptogenic Stroke.Radiologic clinics of North America · 2023
    Review
  4. Advanced cross-sectional imaging of cerebral aneurysms.The British journal of radiology · 2023
    Review
  5. Review
  6. Article
  7. Vessel Wall MR Imaging in the Pediatric Head and Neck.Magnetic resonance imaging clinics of North America · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Vessel wall imaging for intracranial vascular disease evaluation.Journal of neurointerventional surgery · 2016
    Review
  17. Clinical implications of vessel wall imaging-State-of-the-art review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Adam de HavenonDepartment of Neurology, University of Utah, 175 North Medical Drive, Salt Lake City, UT 84132, USA.
Chun YuanDepartment of Radiology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA.
David TirschwellDepartment of Neurology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA.
Thomas HatsukamiDepartment of Radiology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA.
Yoshimi AnzaiDepartment of Radiology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA.
Kyra BeckerDepartment of Neurology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA.
Ali Sultan-QurraieDepartment of Neurology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA.
Mahmud Mossa-BashaDepartment of Radiology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA.
University of Washington · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracranial atherosclerotic disease (ICAD) accounts for 9-15% of ischemic stroke in the United States. Although highly stenotic ICAD accounts for most of the strokes, it is assumed that nonstenotic ICAD (nICAD) can result in stroke, despite being missed on standard luminal imaging modalities. We describe a patient with nICAD who suffered recurrent thromboembolic stroke and TIA but had a negative conventional stroke workup. As a result, they were referred for high-resolution magnetic resonance imaging (HR-MRI) of the arterial vessel wall, which identified a nonstenotic plaque with multiple high-risk features, identifying it as the etiology of the patient's thromboembolic events. The diagnosis resulted in a transition from anticoagulation to antiplatelet therapy, after which the patient's clinical events resolved. HR-MRI is an imaging technique that has the potential to guide medical management for patients with ischemic stroke, particularly in cryptogenic stroke.

Identifiers

PMID26346855
PMCPMC4543789
OpenAlexW1558259246

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.