ArticleFrontiers in aging neuroscience2015
Elevated body mass index and maintenance of cognitive function in late life: exploring underlying neural mechanisms.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Novel Insights Into the Causal Effects and Shared Genetics Between Body Fat and Parkinson Disease.CNS neuroscience & therapeutics · 2024Pooled it
- Trial
- The relationship between changes in body weight and cognitive function in the elderly.International journal of obesity (2005) · 2026Article
- Systematic analysis of associations between obesity and memory decline.GeroScience · 2026Article
- Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study.Neurology · 2024Article
- The Association between cognitive impairment and anthropometric indices among the elderly: birjand longitudinal aging study.Journal of diabetes and metabolic disorders · 2024Article
- The Association of Body Mass Index with Cognition and Alzheimer's Disease Biomarkers in the Elderly with Different Cognitive Status: A Study from the Alzheimer's Disease Neuroimaging Initiative Database.Journal of Alzheimer's disease reports · 2024Article
- The Association of Obesity and Overweight with Executive Functions in Community-Dwelling Older Women.International journal of environmental research and public health · 2023Article
- Time course efficiency of MICE and HIIE on inhibitory control and HRV in adolescents with obesity and different cardiorespiratory fitness.Frontiers in psychology · 2023Article
- Association of Obesity with Cognitive Impairment and Depression among Oldest Old Population having Frailty syndrome.Journal of frailty, sarcopenia and falls · 2022Article
- Obesity marker trajectories and cognitive impairment in older adults: a 10-year follow-up in Taichung community health study for elders.BMC psychiatry · 2022Article
- Article
- The Neglected Factor in the Relationship between Executive Functioning and Obesity: The Role of Motor Control.Healthcare (Basel, Switzerland) · 2022Article
- Article
- Correlation between Body Mass Index (BMI) and Performance on the Montreal Cognitive Assessment (MoCA) in a Cohort of Adult Women in South Africa.Behavioural neurology · 2022Article
- Building research in diet and cognition (BRIDGE): Baseline characteristics of older obese African American adults in a randomized controlled trial to examine the effect of the Mediterranean diet with and without weight loss on cognitive functioning.Preventive medicine reports · 2021Article
- BMI, functional and cognitive status in a cohort of nonagenarians: results from the Mugello study.European geriatric medicine · 2021Article
- Obesity Is Less Frequently Associated with Cognitive Impairment in Elderly Individuals: A Cross-Sectional Study in Yogyakarta, Indonesia.Nutrients · 2020Article
- Inflammation Mediates Body Weight and Ageing Effects on Psychomotor Slowing.Scientific reports · 2019Article
- The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease.Journal of clinical neurology (Seoul, Korea) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is associated with vascular risk factors that in turn, may increase dementia risk. However, higher body mass index (BMI) in late life may be neuroprotective. The possible neural mechanisms underlying the benefit of higher BMI on cognition in older adults are largely unknown. Thus, we used functional connectivity magnetic resonance imaging (fcMRI) to examine: (1) the relationship between BMI and functional brain connectivity; and (2) the mediating role of functional brain connectivity in the association between baseline BMI and change in cognitive function over a 12-month period.
methodsWe conducted a 12-month, prospective study among 66 community-dwelling older adults, aged 70 to 80 years, who were categorized as: normal weight (BMI from 18.50 to 24.99); overweight (BMI from 25.00 to 29.99); and obese (BMI ≥ 30.00). At baseline, participants performed a finger-tapping task during fMRI scanning. Relevant neural networks were initially identified through independent component analysis (ICA) and subsequently examined through seed-based functional connectivity analysis. At baseline and 12-months, we measured three executive cognitive processes: (1) response inhibition; (2) set shifting; and (3) working memory.
resultsObese individuals showed lower task-related functional connectivity during finger tapping in the default mode network (DMN) compared with their healthy weight counterparts (p < 0.01). Lower task-related functional connectivity in the DMN at baseline was independently associated with better working memory performance at 12-months (p = 0.02). Finally, DMN functional connectivity during finger tapping significantly mediated the relationship between baseline BMI and working memory at 12-months (indirect effect: -0.155, 95% confidence interval [-0.313, -0.053]).
conclusionsThese findings suggest that functional connectivity of the DMN may be an underlying mechanism by which higher BMI confers protective effects to cognition in late life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.