ArticleEuropean journal of applied physiology2016
Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women.
Article in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Probiotic supplementation preserves oxygen saturation during severe hypobaric hypoxia in lowland and high-altitude populations.iScience · 2026Article
- Differential homeostatic reorganization during high-altitude trekking: multisystemic adaptations and organ-specific resilience.European journal of applied physiology · 2026Article
- Sex-Specific Epigenetic Patterns in Endocannabinoid System Genes Following High-Altitude Exposure: An Exploratory Study.Brain sciences · 2026Article
- Dimethyl fumarate alleviates inflammation during high altitude hypoxia induced acute lung injury by upregulating Nrf2/SLC7A11 pathway in ferroptosis.Clinical proteomics · 2025Article
- Recommendations for Women in Mountain Sports and Hypoxia Training/Conditioning.Sports medicine (Auckland, N.Z.) · 2024Review
- Fertility Impairment after Trekking at High Altitude: A Proof of Mechanisms on Redox and Metabolic Seminal Changes.International journal of molecular sciences · 2022Article
- Feeding Your Himalayan Expedition: Nutritional Signatures and Body Composition Adaptations of Trekkers and Porters.Nutrients · 2021Article
- Effect of high-altitude trekking on blood pressure and on asymmetric dimethylarginine and isoprostane production: Results from a Mount Ararat expedition.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Muscle Oxygen Delivery in the Forearm and in theFrontiers in physiology · 2020Article
- Body Composition and Body Weight Changes at Different Altitude Levels: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2019Review
- Locomotion as a Powerful Model to Study Integrative Physiology: Efficiency, Economy, and Power Relationship.Frontiers in physiology · 2018Article
- Physiological effects of high-altitude trekking on gonadal, thyroid hormones and macrophage migration inhibitory factor (MIF) responses in young lowlander women.Physiological reports · 2017Article
- Does the Running Economy Really Increase after Ultra-Marathons?Frontiers in physiology · 2017Article
- The Energetics during the World's Most Challenging Mountain Ultra-Marathon-A Case Study at the Tor des Geants®.Frontiers in physiology · 2017Article
- The Regenerative Potential of Female Skeletal Muscle upon Hypobaric Hypoxic Exposure.Frontiers in physiology · 2016Article
- An Extreme Mountain Ultra-Marathon Decreases the Cost of Uphill Walking and Running.Frontiers in physiology · 2016Article
- Low Intensity Exercise Training Improves Skeletal Muscle Regeneration Potential.Frontiers in physiology · 2015Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe investigated the effects of moderate-intensity training at low and high altitude on VO2 and QaO2 kinetics and on myosin heavy-chain expression (MyHC) in seven women (36.3 yy ± 7.1; 65.8 kg ± 11.7; 165 cm ± 8) who participated in two 12- to 14-day trekking expeditions at low (598 m) and high altitude (4132 m) separated by 4 months of recovery.
methodsBreath-by-breath VO2 and beat-by-beat QaO2 at the onset of moderate-intensity cycling exercise and energy cost of walking (Cw) were assessed before and after trekking. MyHC expression of vastus lateralis was evaluated before and after low-altitude and after high-altitude trekking; muscle fiber high-resolution respirography was performed at the beginning of the study and after high-altitude trekking.
resultsMean response time of VO2 kinetics was faster (P = 0.002 and P = 0.001) and oxygen deficit was smaller (P = 0.001 and P = 0.0004) after low- and high-altitude trekking, whereas ˙ QaO2 kinetics and Cw did not change. Percentages of slow and fast isoforms of MyHC and mitochondrial mass were not affected by low- and high-altitude training. After training altitude, muscle fiber ADP-stimulated mitochondrial respiration was decreased as compared with the control condition (P = 0.016), whereas leak respiration was increased (P = 0.031), leading to a significant increase in the respiratory control ratio (P = 0.016).
conclusionsAlthough training did not significantly modify muscle phenotype, it induced beneficial adaptations of the oxygen transport-utilization systems witnessed by faster VO2 kinetics at exercise onset.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.