ReviewJournal of the International Society of Sports Nutrition2015
A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism.
Review in Journal of the International Society of Sports Nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Meta-analysis of probiotic metabolites in the prevention of gestational weight gain and postpartum weight retention.Frontiers in cellular and infection microbiology · 2025Pooled it
- Pooled it
- The effects of conjugated linoleic acid supplementation on lipid profile in adults: A systematic review and dose-response meta-analysis.Frontiers in nutrition · 2022Pooled it
- The effects of a thermogenic supplement on metabolic and hemodynamic variables and subjective mood states.Journal of the International Society of Sports Nutrition · 2023Trial
- Chronic Thermogenic Dietary Supplement Consumption: Effects on Body Composition, Anthropometrics, and Metabolism.Nutrients · 2023Trial
- Trial
- Combined functional lipids modulate lipid metabolism and attenuate metabolic dysregulation in a rat model of cafeteria diet.Journal of physiology and biochemistry · 2026Article
- Effects of linoleic acid and its trans-10 biohydrogenation intermediates (trans-10, cis-12 conjugated linoleic acid and trans-10 18:1) on lipogenic gene expression and Δ9-desaturation indices in bovine intramuscular adipocytes.Journal of animal science · 2026Article
- Review
- The Dual Role of Conjugated Linoleic Acid in Obesity and Metabolic Disorders.Food science & nutrition · 2025Review
- Preslaughter practices, pork physicochemical attributes and fatty acid profiles of pigs raised and slaughtered on smallholder urban farms in the Cape Metropole, South Africa.Veterinary and animal science · 2025Article
- From Obesity to Mitochondrial Dysfunction in Peripheral Tissues and in the Central Nervous System.Biomolecules · 2025Review
- Review
- Insights into the gut microbiome-metabolite dynamics in breast cancer.Gut microbes reports · 2025Review
- Effects of Conjugated Linoleic Acid (CLA) Supplementation and Exposure of Cigarette Smoke on Bcl-2, P53 Protein, and TNF-α Expression in the Epitels of Wistar Rats (Rattus Norvegicus) Bladder.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Production of Conjugated Linoleic Acid (CLA) byFoods (Basel, Switzerland) · 2024Review
- Article
- Conjugated linoleic acid and glucosamine supplements may prevent bone loss in aging by regulating the RANKL/RANK/OPG pathway.Molecular biology reports · 2023Review
- Progress of Conjugated Linoleic Acid on Milk Fat Metabolism in Ruminants and Humans.Animals : an open access journal from MDPI · 2023Review
- Biofortification of cow milk through dietary supplementation with sunflower oil: fatty acid profile, atherogenicity, and thrombogenic index.Tropical animal health and production · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conjugated linoleic acid (CLA) is highly found in fats from ruminants and it appears to favorably modify the body composition and cardiometabolic risk factors. The capacity of CLA to reduce the body fat levels as well as its benefic actions on glycemic profile, atherosclerosis and cancer has already been proved in experimental models. Furthermore, CLA supplementation may modulate the immune function, help re-synthetize of glycogen and potentiate the bone mineralization. CLA supplementation also could increase the lipolysis and reduce the accumulation of fatty acids on the adipose tissue; the putative mechanisms involved may be its action in reducing the lipase lipoprotein activity and to increase the carnitine-palmitoil-transferase-1 (CAT-1) activity, its interaction with PPARγ, and to raise the expression of UCP-1. Although studies made in human have shown some benefits of CLA supplementation as the weight loss, the results are still discordant. Moreover, some have shown adverse effects, such as negative effects on glucose metabolism and lipid profile. The purpose of this article is to review the available data regarding the benefits of CLA on the energetic metabolism and body composition, emphasizing action mechanisms.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.