ArticleNeuroImage. Clinical2015
High-field magnetic resonance imaging of the human temporal lobe.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Reduced structural connectivity of the medial temporal lobe including the perforant path is associated with aging and verbal memory impairment.Neurobiology of aging · 2023Article
- Hippocampal dentate gyrus integrity revealed with ultrahigh resolution diffusion imaging predicts memory performance in older adults.Hippocampus · 2022Article
- Mesoscale diffusion magnetic resonance imaging of the ex vivo human hippocampus.Human brain mapping · 2020Article
- Quantitative synchrotron X-ray tomography of the material-tissue interface in rat cortex implanted with neural probes.Scientific reports · 2019Article
- Post-mortem inference of the human hippocampal connectivity and microstructure using ultra-high field diffusion MRI at 11.7 T.Brain structure & function · 2018Article
- Cognition and connectomes in nondementia idiopathic Parkinson's disease.Network neuroscience (Cambridge, Mass.) · 2018Article
- The hippocampus: detailed assessment of normative two-dimensional measurements, signal intensity, and subfield conspicuity on routine 3T T2-weighted sequences.Surgical and radiologic anatomy : SRA · 2017Article
- Robust diffusion tensor imaging by spatiotemporal encoding: Principles and in vivo demonstrations.Magnetic resonance in medicine · 2017Article
- Toward 20 T magnetic resonance for human brain studies: opportunities for discovery and neuroscience rationale.Magma (New York, N.Y.) · 2016Review
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Authors and funding
9 authors at 3 institutions in 1 country.
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Abstract
backgroundEmerging high-field diffusion weighted MR imaging protocols, along with tractography, can elucidate microstructural changes associated with brain disease at the sub-millimeter image resolution. Epilepsy and other neurological disorders are accompanied by structural changes in the hippocampal formation and associated regions; however, these changes can be subtle and on a much smaller scale than the spatial resolution commonly obtained by current clinical magnetic resonance (MR) protocols in vivo.
methodsWe explored the possibility of studying the organization of fresh tissue with a 17.6 Tesla magnet using diffusion MR imaging and tractography. The mesoscale organization of the temporal lobe was estimated using a fresh unfixed specimen obtained from a subject who underwent anterior temporal lobectomy for medically refractory temporal lobe epilepsy (TLE). Following ex vivo imaging, the tissue was fixed, serial-sectioned, and stained for correlation with imaging.
findingsWe resolved tissue microstructural organizational features in the temporal lobe from diffusion MR imaging and tractography in fresh tissue.
conclusionsFresh ex vivo MR imaging, along with tractography, revealed complex intra-temporal structural variation corresponding to neuronal cell body layers, dendritic fields, and axonal projection systems evident histologically. This is the first study to describe in detail the human temporal lobe structural organization using high-field MR imaging and tractography. By preserving the 3-dimensional structures of the hippocampus and surrounding structures, specific changes in anatomy may inform us about the changes that occur in TLE in relation to the disease process and structural underpinnings in epilepsy-related memory dysfunction.
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