← Insulin × glycemic control

TrialJournal of diabetes science and technology2015

IDegLira Improves Both Fasting and Postprandial Glucose Control as Demonstrated Using Continuous Glucose Monitoring and a Standardized Meal Test.

Jens J Holst et al.PubMed ↗Full text ↗Publisher ↗

  • IDegLiralooks good hereLower PPG increment, no clear effect on PPG increment.Randomised, large.

What the trial testedrandomised · 1,663 people · 2015

Randomised vs insulin degludec

Lowered PPG increment

−12.8mg/dl−21.1 to −4.68

IDegLira vs insulin degludec

As reported

difference −12.79 mg/dl, 95% CI −21.1 to −4.68 · the paper's word: mean PPG increment (normalized iAUC0-4h)

Randomised vs insulin degludec

Lowered PPG increment

−6.13mg/dl−10.3 to −1.98

IDegLira vs insulin degludec

As reported

difference −6.13 mg/dl, 95% CI −10.3 to −1.98 · the paper's word: change from baseline in PPG increment (iAUC0-4h)

Range includes no effect

No clear effect on PPG increment

−1.62mg/dl−10.1 to +6.67

IDegLira vs liraglutide

As reported

difference −1.62 mg/dl, 95% CI −10.1 to 6.67 · the paper's word: mean PPG increment (normalized iAUC0-4h)

Range includes no effect

No clear effect on PPG increment

−1.80mg/dl−2.52 to +5.95

IDegLira vs liraglutide

As reported

difference −1.80 mg/dl, 95% CI −2.52 to 5.95 · the paper's word: change from baseline in PPG increment (iAUC0-4h)

Who was studied, and how

1,663people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

IDegLira
insulin degludec

Lowered PPG increment−12.8

randomised

The trial randomly assignedassigned by chance

IDegLira
liraglutide

No clear effect on PPG increment−1.62

randomised

the abstract, start to end

… (estimated treatment difference [ETD] -12.79 mg/dl [95% CI: -21.08; -4.68], P = .0023) and a similar magnitude of decrease as liraglutide (ETD -1.62 mg/dl [95% CI: -10.09; 6.67], P …

… degludec over all 3 main meals (ETD -6.13 mg/dl [95% CI: -10.27, -1.98], P = .0047) and similar reductions versus liraglutide (ETD -1.80 mg/dl [95% CI: -2.52, 5.95], P …

← favours treatmentfavours comparator →
could be chance
Mean PPG increment (normalized iAUC0-4h)IDegLira vs insulin degludec
−12.79−21.1 to −4.68
Mean PPG increment (normalized iAUC0-4h)IDegLira vs liraglutide
−1.62−10.1 to 6.67
Change from baseline in PPG increment (iAUC0-4h)IDegLira vs insulin degludec
−6.13−10.3 to −1.98
Change from baseline in PPG increment (iAUC0-4h)IDegLira vs liraglutide
−1.80−2.52 to 5.95
InsulinGlycemic control
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12 papers cite it

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The trial

NCT01336023phase 31,663 enrolled2011
Full record →Abstract, authors, funding and every citing paper · PMID 26443290