← Metformin × all-cause mortality

SynthesisThe oncologist2015

Metformin Use Is Associated With Better Survival of Breast Cancer Patients With Diabetes: A Meta-Analysis.

Hong Xu et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 2,760 people · 2015

Not counted

Reduced deaths

−65%−85% to −16%

Bigger than almost all for all-cause mortality

As reported

HR 0.35, 95% CI 0.15–0.84 · the paper's word: All-cause mortality

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with fewer deaths

−47%−61% to −29%

Bigger than 9 in 10 for all-cause mortality

As reported

HR 0.53, 95% CI 0.39–0.71 · the paper's word: All-cause mortality

Correlation · may be no link

No clear link with deaths

−11%−21% to +0%

Bigger than 3 in 10 for all-cause mortality

As reported

HR 0.89, 95% CI 0.79–1.00 · the paper's word: All-cause mortality

Three numbers in the abstract

the abstract, start to end

… with better overall survival times (HR: 0.53; 95% CI: 0.39-0.71) and cancer-specific survival times (HR: 0.89; 95% CI: 0.79-1.00).

… for hormone receptor expression (HR: 0.35; 95% CI: 0.15-0.84).

← favours treatmentfavours comparator →
could be chance
All-cause mortality
HR 0.530.39–0.71
All-cause mortality
HR 0.890.79–1.00
All-cause mortality
HR 0.350.15–0.84
MetforminAll-cause mortality
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Full record →Abstract, authors, funding and every citing paper · PMID 26446233