ArticleJundishapur journal of microbiology2015
Human Cytomegalovirus in Oral Squamous Cell Carcinoma in Southeast of Iran.
Article in Jundishapur journal of microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- HPV, EBV, CMV, and HSV in Head and Neck Cancer: Molecular Detection, Seroprevalence, and Clinical Correlations.Biology · 2025Article
- Review
- Biological biomarkers of oral cancer.Periodontology 2000 · 2024Review
- Friend or Foe? Exploring the Role of Cytomegalovirus (HCMV) Infection in Head and Neck Tumors.Biomedicines · 2024Article
- Oral microbiota and oral squamous cell carcinoma: a review of their relation and carcinogenic mechanisms.Frontiers in oncology · 2024Review
- Human cytomegalovirus alters immune cell profile with potential implications for patient survival in head and neck cancer.Carcinogenesis · 2022Article
- Mapping human papillomavirus, Epstein-Barr virus, cytomegalovirus, adenovirus, and p16 in laryngeal cancer.Discover oncology · 2022Article
- The Role of the Oral Microbiota in the Etiopathogenesis of Oral Squamous Cell Carcinoma.Microorganisms · 2021Review
- Apoptosis Disorder, a Key Pathogenesis of HCMV-Related Diseases.International journal of molecular sciences · 2021Review
- Role of EGFR gene polymorphisms in oral squamous cell carcinoma patients of Southeast Iran: A case-control study.Caspian journal of internal medicine · 2020Article
- Interplay between viruses and bacterial microbiota in cancer development.Seminars in immunology · 2017Review
- The interaction between human papillomavirus and other viruses.Virus research · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarcinogenesis is a multi-step process and the role of infectious agents in this progression has not been fully identified. Since human cytomegalovirus (HCMV) is frequently presented in the gingival sulcus fluid, we hypothesized that this virus would be important in the pathogenesis of oral squamous cell carcinoma (OSCC).
objectivesThe aim of this study was to investigate the presence of active HCMV in different histopathological grades of OSCC in southeast of Iran. MATERIALS AND
methodsForty eight individual specimens were evaluated in this study. Serial sections were obtained from paraffin-embedded tissue samples of OSCC biopsies. The frequency of HCMV was investigated using the real-time polymerase change reaction method after DNA extraction from biopsies.
resultsThe mean age of the patients (66.7% female and 33.3% male) was 58.6 years. Only three cases (6.3%) of the grade I, OSCC biopsies, were positive for active HCMV with average load of 57.7 × 10(3).
conclusionsAccording to the low prevalence of HCMV in OSCC, it seems that this virus plays a minor role in this kind of cancer at least in southeast of Iran. More comprehensive studies are needed to investigate the oncomodulatory effect of this virus on OSCC.
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