ArticleHuman brain mapping2015
Insight and psychosis: Functional and anatomical brain connectivity and self-reflection in Schizophrenia.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex and Diffusion Tensor Imaging of White Matter in Schizophrenia: A Systematic Review Plus Meta-analysis of the Corpus Callosum.Schizophrenia bulletin · 2018Pooled it
- Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study.Schizophrenia (Heidelberg, Germany) · 2025Article
- The neural correlates of illness awareness in addiction: a pilot exploratory analysis of preliminary data from the cognitive dysfunction in the addictions (CDiA) research program.Frontiers in neurology · 2025Article
- The unique role of anosognosia in the clinical progression of Alzheimer's disease: a disorder-network perspective.Communications biology · 2024Review
- The network characteristics in schizophrenia with prominent negative symptoms: a multimodal fusion study.Schizophrenia (Heidelberg, Germany) · 2024Article
- Structure/function interrelationships and illness insight in patients with schizophrenia: a multimodal MRI data fusion study.European archives of psychiatry and clinical neuroscience · 2023Article
- Neural substrates of verbal memory impairment in schizophrenia: A multimodal connectomics study.Human brain mapping · 2023Article
- Cortical thinning in relation to impaired insight into illness in patients with treatment resistant schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Associations between Family Functioning and Maternal Behavior on Default Mode Network Connectivity in School-Age Children.International journal of environmental research and public health · 2022Article
- Causal connectivity from right DLPFC to IPL in schizophrenia patients: a pilot study.Schizophrenia (Heidelberg, Germany) · 2022Article
- Association Between Lack of Insight and Prefrontal Serotonin Transporter Availability in Antipsychotic-Free Patients with Schizophrenia: A High-Resolution PET Study with [Neuropsychiatric disease and treatment · 2021Article
- Structural and Functional Default Mode Network Connectivity and Antipsychotic Treatment Response in Medication-Naïve First Episode Psychosis Patients.Schizophrenia bulletin open · 2021Article
- Altered reward-related effective connectivity in obsessive-compulsive disorder: an fMRI studyJournal of psychiatry & neuroscience : JPN · 2019Article
- Brain function differences in drug-naïve first-episode auditory verbal hallucination-schizophrenia patients with versus without insight.Chinese medical journal · 2019Article
- Impaired illness awareness in schizophrenia and posterior corpus callosal white matter tract integrity.NPJ schizophrenia · 2019Article
- The Multiple Dimensions of Insight in Schizophrenia-Spectrum Disorders.Schizophrenia bulletin · 2019Review
- Spatial Dynamic Functional Connectivity Analysis Identifies Distinctive Biomarkers in Schizophrenia.Frontiers in neuroscience · 2019Article
- Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naïve adults with obsessive-compulsive disorder.NeuroImage. Clinical · 2019Article
- Review
- Stronger default mode network connectivity is associated with poorer clinical insight in youth at ultra high-risk for psychotic disorders.Schizophrenia research · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impaired insight into illness, associated with worse treatment outcome, is common in schizophrenia. Insight has been related to the self-reflective processing, centred on the medial frontal cortex. We hypothesized that anatomical and functional routes to and from the ventromedial prefrontal cortex (vmPFC) would differ in patients according to their degree of impaired insight. Forty-five schizophrenia patients and 19 healthy subjects performed a self-reflection task during fMRI, and underwent diffusion tensor imaging. Using dynamic causal modelling we observed increased effective connectivity from the posterior cingulate cortex (PCC), inferior parietal lobule (IPL), and dorsal mPFC (dmPFC) towards the vmPFC with poorer insight and decrease from vmPFC to the IPL. Stronger connectivity from the PCC to vmPFC during judgment of traits related to self was associated with poorer insight. We found small-scale significant changes in white matter integrity associated with clinical insight. Self-reflection may be influenced by synaptic changes that lead to the observed alterations in functional connectivity accompanied by the small-scale but measurable alterations in anatomical connections. Our findings may point to a neural compensatory response to an impairment of connectivity between self-processing regions. Similarly, the observed hyper-connectivity might be a primary deficit linked to inefficiency in the component cognitive processes that lead to impaired insight. We suggest that the stronger cognitive demands placed on patients with poor insight is reflected in increased effective connectivity during the task in this study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.