Evidence map›Paper›PMID 26467779›Full record

Trial reportJournal of the American Society of Nephrology : JASN2016

Long-Term Effects of Frequent In-Center Hemodialysis.

Glenn M Chertow, Nathan W Levin, Gerald J Beck, John T Daugirdas, Paul W Eggers, Alan S Kliger, Brett Larive, Michael V Rocco, Tom Greene, Frequent Hemodialysis Network (FHN) Trials Group

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03239808 naactive not recruitingnot on this mapstarted 2018, after this paper: background citation

Assessment of the Incremental Haemodialysis Security and Effectiveness in Incident Patients

TypeinterventionalSponsorFundación para la Formación e Investigación de los Profesionales de la Salud de ExtremaduraRan2018 to 2025Enrolled152ConditionsRenal Disease, End-StageArmsIncremental haemodialysis, Conventional haemodialysis
NCT03994133 unknown statusnot on this mapstarted 2019, after this paper: background citation

Contribution of Body Composition Monitor (BCM) Among Patients Using Daily Home Dialysis With Low Dialysate Flow : French Study Cohort

TypeobservationalSponsorUniversity Hospital, CaenRan2019 to 2020Enrolled85ConditionsChronic Kidney Disease Requiring Chronic Dialysis, Hemodialysis, Home, Electric ImpedanceArmsMeasurement of the hydration state by bio-impedance spectroscopy
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Interventions for fatigue in people with kidney failure requiring dialysis.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Guideline
  4. A Trial of Extending Hemodialysis Hours and Quality of Life.Journal of the American Society of Nephrology : JASN · 2017
    Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Observational
  14. Review
  15. Post-dialysis recovery time in ESRD patients receiving more frequent hemodialysis in skilled nursing facilities.Hemodialysis international. International Symposium on Home Hemodialysis · 2022
    Article
  16. Patient Preferences for Longer or More Frequent In-Center Hemodialysis Regimens: A Multicenter Discrete Choice Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022
    Article
  17. Review
  18. Volume overload in hemodialysis: diagnosis, cardiovascular consequences, and management.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Glenn M ChertowDepartment of Medicine, Stanford University, Palo Alto, California; gchertow@stanford.edu.
Nathan W LevinRenal Research Institute, New York, New York;
Gerald J BeckCleveland Clinic Foundation, Cleveland, Ohio;
John T DaugirdasUniversity of Illinois, Chicago, Illinois;
Paul W EggersNational Institutes of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland;
Alan S KligerYale University, New Haven, Conneticut;
Brett LariveCleveland Clinic Foundation, Cleveland, Ohio;
Michael V RoccoWake Forest University, Winston-Slem, North Carolina; and.
Tom GreeneCleveland Clinic Foundation, Cleveland, Ohio; University of Utah, Salt Lake City, Utah.
Frequent Hemodialysis Network (FHN) Trials Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Frequent Hemodialysis Network Daily Trial randomized 245 patients to receive six (frequent) or three (conventional) in-center hemodialysis sessions per week for 12 months. As reported previously, frequent in-center hemodialysis yielded favorable effects on the coprimary composite outcomes of death or change in left ventricular mass and death or change in self-reported physical health. Here, we determined the long-term effects of the 12-month frequent in-center hemodialysis intervention. We determined the vital status of patients over a median of 3.6 years (10%-90% range, 1.5-5.3 years) after randomization. Using an intention to treat analysis, we compared the mortality hazard in randomized groups. In a subset of patients from both groups, we reassessed left ventricular mass and self-reported physical health a year or more after completion of the intervention; 20 of 125 patients (16%) randomized to frequent hemodialysis died during the combined trial and post-trial observation periods in contrast to 34 of 120 patients (28%) randomized to conventional hemodialysis. The relative mortality hazard for frequent versus conventional hemodialysis was 0.54 (95% confidence interval, 0.31 to 0.93); with censoring of time after kidney transplantation, the relative hazard was 0.56 (95% confidence interval, 0.32 to 0.99). Bayesian analysis suggested a relatively high probability of clinically significant benefit and a very low probability of harm with frequent hemodialysis. In conclusion, a 12-month frequent in-center hemodialysis intervention significantly reduced long-term mortality, suggesting that frequent hemodialysis may benefit selected patients with ESRD.

Indexed as

HumansKidney Failure, ChronicMiddle AgedRenal DialysisTime Factorsclinical trialend-stage renal diseasehemodialysis

Identifiers

PMID26467779
PMCPMC4884113

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.