ReviewExpert review of clinical immunology2016
Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy.
Review in Expert review of clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05197387 (Inflammation in Intrahepatic Cholestasis of Pregnancy), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Inflammation in Intrahepatic Cholestasis of Pregnancy
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of gut microbiome on intrahepatic cholestasis of pregnancy-systematic literature review.Frontiers in medicine · 2026Pooled it
- Diagnostic and Prognostic Value of Long Noncoding RNAs as Potential Novel Biomarkers in Intrahepatic Cholestasis of Pregnancy.BioMed research international · 2021Trial
- Inflammatory hematologic indices in intrahepatic cholestasis of pregnancy: a retrospective case-control study focusing on the aggregate index of systemic inflammation.BMC pregnancy and childbirth · 2026Article
- Intrahepatic Cholestasis of Pregnancy: Neonatal Impact Through the Lens of Current Evidence.Biomedicines · 2025Review
- Assessment of the fetal thymic-thoracic ratio in pregnant women with intrahepatic cholestasis: a prospective case-control study.Journal of perinatal medicine · 2024Article
- Evaluation of Serum Calprotectin as an Alternative Diagnostic Marker for Intrahepatic Cholestasis of Pregnancy.Journal of clinical medicine · 2024Article
- ICP - could there be a virus in the works?Obstetric medicine · 2024Review
- Evaluation of Prenatal Comfort, Sleep, and Quality of Life in Pregnant Women with Cholestasis: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- The effect of intrahepatic cholestasis in pregnancy combined with different stages of hepatitis B virus infection on pregnancy outcomes: a retrospective study.BMC pregnancy and childbirth · 2024Article
- Comprehensive Analysis of scRNA-Seq and Bulk RNA-Seq Reveals Transcriptional Signatures of Macrophages in Intrahepatic Cholestasis of Pregnancy.Journal of inflammation research · 2024Article
- Causal association between gut microbiota and intrahepatic cholestasis of pregnancy: mendelian randomization study.BMC pregnancy and childbirth · 2023Article
- Unique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy.BMC pregnancy and childbirth · 2023Article
- The role of noncoding RNA and its diagnostic potential in intrahepatic cholestasis of pregnancy: a research update.Frontiers in genetics · 2023Review
- Perinatal outcomes of intrahepatic cholestasis of pregnancy from two birth cohorts: A population-based study.Obstetric medicine · 2022Article
- Prevalence, risk factors and adverse perinatal outcomes for Chinese women with intrahepatic cholestasis of pregnancy: a large cross-sectional retrospective study.Annals of medicine · 2022Article
- Identification of two novel pathogenic variants of the NR1H4 gene in intrahepatic cholestasis of pregnancy patients.BMC medical genomics · 2022Article
- Molecular Pathogenesis of Intrahepatic Cholestasis of Pregnancy.Canadian journal of gastroenterology & hepatology · 2021Review
- Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes and preeclampsia.Annals of translational medicine · 2020Article
- Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.Nature reviews. Drug discovery · 2020Review
- Beneficial and Deleterious Effects of Female Sex Hormones, Oral Contraceptives, and Phytoestrogens by Immunomodulation on the Liver.International journal of molecular sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Intrahepatic cholestasis of pregnancy poses a great risk to both maternal and fetal health. Despite extensive research, much of the pathogenesis of this disorder is unknown. The increase in bile acids observed in patients with intrahepatic cholestasis of pregnancy has been noted to cause a change in the immune system from the normally mediated TH2 response to one that is more oriented towards TH1. In this literature review, we have critically reviewed the current literature regarding the changes in the immune system and the potential effects of immunological changes in the management of the patient. The current treatment, ursodeoxycholic acid, is also discussed along with potential combination therapies and future directions for research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.