ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2016
Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules.
Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 151 citations in OpenAlex.
- Voluntary wheel running prevented the short-term behavioural effects of vicarious intermittent social defeat in female mice.Psychopharmacology · 2026Article
- Transcriptomic signatures in tetrapartite brain region identifies shared and unique gene signatures for substance-use.Frontiers in cellular neuroscience · 2026Article
- Behavioral profile predicts ethanol preference in adolescent mice, but not in adults: A machine learning approach.Alcohol, clinical & experimental research · 2026Article
- Gestational physical exercise prevents early-life behavioral impairments in the offspring of a rat model of attention deficit hyperactivity disorder.Scientific reports · 2025Article
- Review
- The relationship between personality dimensions and addiction type in women addicted to alcohol and opioids.Scientific reports · 2025Article
- Repeated alcohol drinking in mice is associated with bidirectional alterations in corticostriatal coherence.Neuropharmacology · 2025Article
- Nicotine Withdrawal Drives Aversive Behaviors by Recruiting Inhibitory Interpeduncular Nucleus Inputs to the Laterodorsal Tegmentum in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Charting the Unknown : Sex Differences in Spatial Exploration Across the Lifespan.Human nature (Hawthorne, N.Y.) · 2025Article
- Review
- Nerve growth factor gene polymorphisms may be associated with heroin dependence in women but do not mediate specific personality traits.European archives of psychiatry and clinical neuroscience · 2025Article
- The role of personality traits and life stress in alcohol use disorder: Insights from NGF gene polymorphisms of Han Chinese population in Taiwan.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- Effects of Quetiapine on Novelty-Related Object Recognition Memory and Hippocampal BDNF Level in Sleep-Deprived Rats.Brain and behavior · 2025Article
- Boredom and affective temperaments as factors hindering smoking cessation: An exploration within an Italian sample.AIMS public health · 2025Article
- Linking Striatal Dopaminergic Asymmetry with Personality Traits: Insights from Gambling Disorder.Journal of gambling studies · 2024Article
- Enhanced Novel Object Recognition and Spatial Memory in Rats Selectively Bred for High Nicotine Preference.Brain sciences · 2024Article
- Expectancies of the Effects of Cannabis Use in Individuals with Social Anxiety Disorder (SAD).Brain sciences · 2024Article
- Predictors of drug and substance abuse among school-going adolescents living in drug hotspot in Malaysia.PloS one · 2024Article
- Neurobehavioral Precursors of Compulsive Cocaine Seeking in Dual Frontostriatal Circuits.Biological psychiatry global open science · 2024Article
- Motivations for Cannabis Use in Individuals with Social Anxiety Disorder (SAD).Brain sciences · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Global treatment of drug addiction costs society billions of dollars annually, but current psychopharmacological therapies have not been successful at desired rates. The increasing number of individuals suffering from substance abuse has turned attention to what makes some people more vulnerable to drug addiction than others. One personality trait that stands out as a contributing factor is novelty seeking. Novelty seeking, affected by both genetic and environmental factors, is defined as the tendency to desire novel stimuli and environments. It can be measured in humans through questionnaires and in rodents using behavioral tasks. On the behavioral level, both human and rodent studies demonstrate that high novelty seeking can predict the initiation of drug use and a transition to compulsive drug use and create a propensity to relapse. These predictions are valid for several drugs of abuse, such as alcohol, nicotine, cocaine, amphetamine, and opiates. On the molecular level, both novelty seeking and addiction are modulated by the central reward system in the brain. Dopamine is the primary neurotransmitter involved in the overlapping neural substrates of both parameters. In sum, the novelty-seeking trait can be valuable for predicting individual vulnerability to drug addiction and for generating successful treatment for patients with substance abuse disorders.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.