Evidence map›Paper›PMID 26486356›Full record

ArticleDiabetologia2016

Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers.

Marco Bucci, Ville Huovinen, Maria Angela Guzzardi, Suvi Koskinen, Juho R Raiko, Heta Lipponen, Shaila Ahsan, Robert M Badeau, Miikka-Juhani Honka, Jukka Koffert and 8 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01931540 (Developmental ORIgins of Healthy and Unhealthy AgeiNg), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01931540 nacompletednot on this map

Developmental ORIgins of Healthy and Unhealthy AgeiNg: the Role of Maternal Obesity

TypeinterventionalSponsorTurku University HospitalRan2012 to 2015Enrolled48ConditionsMaternal-Fetal Relations, Muscle Weakness, Insulin ResistanceArmsExercise Training
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Early life programming of health and disease: The long-term consequences of obesity in pregnancy.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022
    Review
  12. Article
  13. Nutrients · 2021
    Review
  14. Review
  15. Muscle Lipid Droplets: Cellular Signaling to Exercise Physiology and Beyond.Trends in endocrinology and metabolism: TEM · 2020
    Review
  16. Article
  17. Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age.International journal of molecular sciences · 2020
    Review
  18. Review
  19. Article
  20. Lipid modulation of skeletal muscle mass and function.Journal of cachexia, sarcopenia and muscle · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Marco BucciTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland. marbuc@utu.fi.
Ville HuovinenTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Maria Angela GuzzardiInstitute of Clinical Physiology, National Research Council, Pisa, Italy.
Suvi KoskinenTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Juho R RaikoTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Heta LipponenTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Shaila AhsanTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Robert M BadeauTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Miikka-Juhani HonkaTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Jukka KoffertTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Nina SavistoTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Minna K SalonenFolkhälsan Research Centre, Helsinki, Finland.
Jonathan AnderssonDepartment of Radiology, Uppsala University, Uppsala, Sweden.
Joel KullbergDepartment of Radiology, Uppsala University, Uppsala, Sweden.
Samuel SandbogeFolkhälsan Research Centre, Helsinki, Finland.
Patricia IozzoTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Johan G ErikssonFolkhälsan Research Centre, Helsinki, Finland.
Pirjo NuutilaTurku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland.
Turku PET Centre · FIFinnish Institute for Health and Welfare · FIUniversity of Turku · FIUppsala University · SEFolkhälsans Forskningscentrum · FINational Research Council · ITTurku University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisMaternal obesity predisposes offspring to adulthood morbidities, including type 2 diabetes. Type 2 diabetes and insulin resistance have been associated with shortened telomere length. First, we aimed to investigate whether or not maternal obesity influences insulin sensitivity and its relationship with leucocyte telomere length (LTL) in elderly women. Second, we tested whether or not resistance exercise training improves insulin sensitivity in elderly frail women.

methodsForty-six elderly women, of whom 20 were frail offspring of lean/normal weight mothers (OLM, BMI ≤26.3 kg/m2) and 17 were frail offspring of overweight/obese mothers (OOM,BMI ≥28.1 kg/m2), were studied before and after a 4 month resistance training (RT) intervention. Muscle insulin sensitivity of glucose uptake was measured using 18F-fluoro-2-deoxyglucose and positron emission tomography with computed tomography during a hyperinsulinaemic–euglycaemic clamp. Muscle mass and lipid content were measured using magnetic resonance and LTL was measured using real-time PCR.

resultsThe OOM group had lower thigh muscle insulin sensitivity compared with the OLM group (p=0.048) but similar whole body insulin sensitivity. RT improved whole body and skeletal muscle insulin sensitivity in the OOM group only (p=0.004 and p=0.013, respectively), and increased muscle mass in both groups (p <0 .01). In addition, in the OOM group, LTL correlated with different thigh muscle groups insulin sensitivity (ρ ≥ 0.53; p ≤ 0.05). Individuals with shorter LTL showed a higher increase in skeletal muscle insulin sensitivity after training (ρ ≥ −0.61; p ≤ 0.05). CONCLUSIONS/

interpretationMaternal obesity and having telomere shortening were associated with insulin resistance in adult offspring. A resistance exercise training programme may reverse this disadvantage among offspring of obese mothers. Trial registration: ClinicalTrials.gov NCT01931540.

Indexed as

Prenatal Exposure Delayed EffectsResistance TrainingAgedFemaleFluorodeoxyglucose F18Frail ElderlyGlucoseHumansHyperinsulinismImage Processing, Computer-AssistedInsulinInsulin ResistanceLeukocytesLeukocytes, MononuclearLipidsMagnetic Resonance ImagingFluorodeoxyglucose F18GlucoseInsulinLipids

Identifiers

PMID26486356
OpenAlexW2175992484

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.