ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2016
Risk of dementia and death in the long-term follow-up of the Pittsburgh Cardiovascular Health Study-Cognition Study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.Nature communications · 2018Pooled it
- Clinical dementia severity associated with ventricular size is differentially moderated by cognitive reserve in men and women.Alzheimer's research & therapy · 2018Trial
- Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years.Journal of the American College of Cardiology · 2016Trial
- Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Trends in hypertensive heart disease-related mortality among population with Alzheimer's in the United States: a 22-year nationwide analysis.Annals of medicine and surgery (2012) · 2025Review
- Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Cardiovascular Disease and Alzheimer's Disease: The Heart-Brain Axis.Journal of the American Heart Association · 2023Review
- Cardiac Troponin, Cognitive Function, and Dementia: A Systematic Review.Aging and disease · 2023Review
- Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Evaluation of Selective Survival and Sex/Gender Differences in Dementia Incidence Using a Simulation Model.JAMA network open · 2021Article
- Cognitive impairment in racially/ethnically diverse older adults: Accounting for sources of diagnostic bias.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Genetic Risk Factors for Alzheimer's Disease in Racial/Ethnic Minority Populations in the U.S.: A Scoping Review.Frontiers in public health · 2021Article
- Cerebral Blood Flow Predicts Conversion of Mild Cognitive Impairment into Alzheimer's Disease and Cognitive Decline: An Arterial Spin Labeling Follow-up Study.Journal of Alzheimer's disease : JAD · 2021Article
- Associations of body composition with incident dementia in older adults: Cardiovascular Health Study-Cognition Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Examining the causal mediating role of brain pathology on the relationship between diabetes and cognitive impairment: the Cardiovascular Health Study.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2020Article
- Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice.Nature communications · 2020Article
- The role of functional status on the relationship between blood pressure and cognitive decline: the Cardiovascular Health Study.Journal of hypertension · 2019Article
- Blood Pressure and Statin Effects on Cognition: a Review.Current hypertension reports · 2019Review
- Amyloid deposition and brain structure as long-term predictors of MCI, dementia, and mortality.Neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionIncreasing life expectancy has resulted in a larger population of older individuals at risk of dementia.
methodsThe Cardiovascular Health Study-Cognition Study followed 532 participants from 1998-99 (mean age 79) to 2013 (mean age 93) for death and dementia.
resultsRisk of death was determined by extent of coronary artery calcium, high-sensitivity cardiac troponin, brain natriuretic peptide, and white matter grade. Significant predictors of dementia were age, apolipoprotein-E4, vocabulary raw score, hippocampal volume, ventricular size, cognitive performance, and number of blocks walked. By 2013, 160 of 532 were alive, including 19 cognitively normal. Those with normal cognition had higher grade education, better cognition test scores, greater hippocampal volume, faster gait speed, and number of blocks walked as compared with survivors who were demented. DISCUSSION: Few survived free of dementia and disability. Prevention and delay of cognitive decline for this older population is an imperative.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.