Evidence map›Paper›PMID 26553349›Full record

ArticleMolecular neurobiology2016

mGluR3 Activation Recruits Cytoplasmic TWIK-1 Channels to Membrane that Enhances Ammonium Uptake in Hippocampal Astrocytes.

Wei Wang, Conrad M Kiyoshi, Yixing Du, Baofeng Ma, Catherine C Alford, Haijun Chen, Min Zhou

Open access · greenAbstract read
In one paragraph

Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. TREK-1 and epilepsy: regulating the balance of KBehavioral and brain functions : BBF · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wei WangDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA. wwang@hust.edu.cn.
Conrad M KiyoshiDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Yixing DuDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Baofeng MaDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Catherine C AlfordDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Haijun ChenDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA.
Min ZhouDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA. zhou.787@osu.edu.
The Ohio State University Wexner Medical Center · USUniversity at Albany, State University of New York · US

Funding

Involvement of astrocytic two-pore domain K+ channels in ischemic pathologyR01NS062784 · NINDS · ORDWAY RESEARCH INSTITUTE, INC. · PI ZHOU, MIN · 2010 to 2014
$1.7M
NINDS NIH HHS R01 NS062784
6 · The paper itself

Abstract

TWIK-1 two-pore domain K

Indexed as

Ammonium CompoundsAnimalsAstrocytesCell MembraneCytoplasmEndocytosisEndosomesExocytosisHippocampusMice, Inbred C57BLMice, KnockoutPotassium Channels, Tandem Pore Domainrab GTP-Binding ProteinsReceptors, Metabotropic GlutamateRNA, MessengerSodium-Potassium-Exchanging ATPaseAmmonium CompoundsKcnk1 protein, mousemetabotropic glutamate receptor 3Potassium Channels, Tandem Pore Domainrab GTP-Binding ProteinsReceptors, Metabotropic GlutamateRNA, MessengerSodium-Potassium-Exchanging ATPaseAmmoniumAstrocytesEndosomal traffickingHippocampusMetabotropic glutamate receptor 3TWIK-1 channel

Identifiers

PMID26553349
PMCPMC4862944
OpenAlexW2120878067

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.