ArticleeLife2015
Multivariate analysis of electrophysiological diversity of Xenopus visual neurons during development and plasticity.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
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- Neural circuit function redundancy in brain disorders.Current opinion in neurobiology · 2021Review
- Early Developmental Exposure to Fluoxetine and Citalopram Results in Different Neurodevelopmental Outcomes.Neuroscience · 2021Article
- Preparations and Protocols for Whole Cell Patch Clamp Recording of Xenopus laevis Tectal Neurons.Journal of visualized experiments : JoVE · 2018Article
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- Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types.NPJ systems biology and applications · 2018Article
- Experience-dependent plasticity of excitatory and inhibitory intertectal inputs in Xenopus tadpoles.Journal of neurophysiology · 2016Article
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- Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits.Neural development · 2016Article
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- A population of gap junction-coupled neurons drives recurrent network activity in a developing visual circuit.Journal of neurophysiology · 2016Article
- Emergence of Selectivity to Looming Stimuli in a Spiking Network Model of the Optic Tectum.Frontiers in neural circuits · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Biophysical properties of neurons become increasingly diverse over development, but mechanisms underlying and constraining this diversity are not fully understood. Here we investigate electrophysiological characteristics of Xenopus tadpole midbrain neurons across development and during homeostatic plasticity induced by patterned visual stimulation. We show that in development tectal neuron properties not only change on average, but also become increasingly diverse. After sensory stimulation, both electrophysiological diversity and functional differentiation of cells are reduced. At the same time, the amount of cross-correlations between cell properties increase after patterned stimulation as a result of homeostatic plasticity. We show that tectal neurons with similar spiking profiles often have strikingly different electrophysiological properties, and demonstrate that changes in intrinsic excitability during development and in response to sensory stimulation are mediated by different underlying mechanisms. Overall, this analysis and the accompanying dataset provide a unique framework for further studies of network maturation in Xenopus tadpoles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.