Other lipid agents × lipids

TrialAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2016

Cost-effectiveness of Simvastatin plus Ezetimibe for Cardiovascular Prevention in CKD: Results of the Study of Heart and Renal Protection (SHARP).

Borislava Mihaylova et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 9,270 people · 2016

Randomised comparison

Lowered lipids

−20.0percentage points−32.0 to −6.00

As reported

difference −20.0 %, 95% CI −32.0 to −6.00

Range includes no effect

No clear effect on kidney outcomes

−3%−10% to +3%

Bigger than 1 in 10 on the map

As reported

RR 0.97, 95% CI 0.90–1.03

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with lower lipids

−17%−28% to −5%

Bigger than 4 in 10 on the map

As reported

IRR 0.83, 95% CI 0.72–0.95

Correlation · may be no link

No clear link with kidney outcomes

+12.0percentage points−6.00 to +27.0

As reported

difference 12 %, 95% CI −6.00 to 27.0

Four numbers in the abstract

the abstract, start to end

in all major atherosclerotic events of 20% (95% CI, 6%-32%) and in the

effect on renal hospital episodes (RR, 0.97; 95% CI, 0.90-1.03; P = 0.3) or

proportional reduction (rate ratio [RR], 0.83; 95% CI, 0.72-0.95; P = 0.007)

in major atherosclerotic events and 12% [95% CI, -6% to 27%] reduction

← favours treatmentfavours comparator →
could be chance
Lipids
−20.0−32.0 to −6.00
Kidney outcomes
RR 0.970.90–1.03
Lipids
IRR 0.830.72–0.95
Kidney outcomes
12−6.00 to 27.0
StatinsOther lipid agentsLipidsKidney outcomes

Other lipid agents × lipidshelps?mixed

unlikelylikely
0.500.50 without it

Other lipid agents × kidney outcomeshelps?no deciding trial

unlikelylikely
0.25only evidence

Statins × lipidshelps?mixed

unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 26597925