Evidence map›Paper›PMID 26607249›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2016

Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults.

Allison E DeVan, Lawrence C Johnson, Forrest A Brooks, Trent D Evans, Jamie N Justice, Charmion Cruickshank-Quinn, Nichole Reisdorph, Nathan S Bryan, Matthew B McQueen, Jessica R Santos-Parker and 5 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Allison E DeVanDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado; adevan@mcw.edu.
Lawrence C JohnsonDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado;
Forrest A BrooksDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado;
Trent D EvansDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado;
Jamie N JusticeDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado;
Charmion Cruickshank-QuinnIntegrated Department of Immunology, National Jewish Health, Denver, Colorado;
Nichole ReisdorphIntegrated Department of Immunology, National Jewish Health, Denver, Colorado;
Nathan S BryanBaylor College of Medicine, Houston, Texas;
Matthew B McQueenDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado;
Jessica R Santos-ParkerDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado;
Michel B ChoncholDivision of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado;
Candace J BassettDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado;
Amy L SindlerDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado;
Tony GiordanoTheraVasc, Cleveland, Ohio.
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado;
University of Colorado Boulder · USNational Jewish Health · USBaylor College of Medicine · USUniversity of Colorado Denver · US

Funding

UCHSC AGING TRAINING GRANTT32AG000279 · UNIVERSITY OF COLORADO DENVER · 2001 to 2025
$2.0M
Human Aging, Exercise &FMD: Translational PhysiologyR37AG013038 · UNIVERSITY OF COLORADO AT BOULDER · 2004 to 2005
$586k
NCATS NIH HHS UL1 TR001082NCRR NIH HHS UL1 RR025780NHLBI NIH HHS R21HL107105NIA NIH HHS R37AG013038NIA NIH HHS T32 AG000279
6 · The paper itself

Abstract

Insufficient nitric oxide (NO) bioavailability plays an important role in endothelial dysfunction and arterial stiffening with aging. Supplementation with sodium nitrite, a precursor of NO, ameliorates age-related vascular endothelial dysfunction and arterial stiffness in mice, but effects on humans, including the metabolic pathways altered, are unknown. The purpose of this study was to determine the safety, feasibility, and efficacy of oral sodium nitrite supplementation for improving vascular function in middle-aged and older adults and to identify related circulating metabolites. Ten weeks of sodium nitrite (80 or 160 mg/day, capsules, TheraVasc; randomized, placebo control, double blind) increased plasma nitrite acutely (5- to 15-fold, P < 0.001 vs. placebo) and chronically (P < 0.10) and was well tolerated without symptomatic hypotension or clinically relevant elevations in blood methemoglobin. Endothelial function, measured by brachial artery flow-mediated dilation, increased 45-60% vs. baseline (P < 0.10) without changes in body mass or blood lipids. Measures of carotid artery elasticity (ultrasound and applanation tonometry) improved (decreased β-stiffness index, increased cross-sectional compliance, P < 0.05) without changes in brachial or carotid artery blood pressure. Aortic pulse wave velocity was unchanged. Nitrite-induced changes in vascular measures were significantly related to 11 plasma metabolites identified by untargeted analysis. Baseline abundance of multiple metabolites, including glycerophospholipids and fatty acyls, predicted vascular changes with nitrite. This study provides evidence that sodium nitrite supplementation is well tolerated, increases plasma nitrite concentrations, improves endothelial function, and lessens carotid artery stiffening in middle-aged and older adults, perhaps by altering multiple metabolic pathways, thereby warranting a larger clinical trial.

Indexed as

AgedAgingAortaBlood PressureBody Mass IndexBrachial ArteryCarotid ArteriesDietary SupplementsDouble-Blind MethodElasticityEndothelium, VascularFemaleHumansMaleMethemoglobinMiddle AgedMethemoglobinNitric OxideSodium Nitritearterial stiffnessendothelial dysfunctionmetabolomics

Identifiers

PMID26607249
PMCPMC4754621
OpenAlexW2278341454

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.