Evidence map›Paper›PMID 26621521›Full record

Trial reportIntegrative cancer therapies2016

YOCAS©® Yoga Reduces Self-reported Memory Difficulty in Cancer Survivors in a Nationwide Randomized Clinical Trial: Investigating Relationships Between Memory and Sleep.

Michelle C Janelsins, Luke J Peppone, Charles E Heckler, Shelli R Kesler, Lisa K Sprod, James Atkins, Marianne Melnik, Charles Kamen, Jeffrey Giguere, Michael J Messino and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Integrative cancer therapies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05180656 (The Impact of a Remotely-Delivered Yoga Intervention on Cognitive Function in Breast Cancer Survivors), which is not on this map. Cited by 54 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 7 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05180656 nacompletednot on this mapstarted 2021, after this paper: background citation

The Impact of a Remotely-Delivered Yoga Intervention on Cognitive Function in Breast Cancer Survivors: A Feasibility Study

TypeinterventionalSponsorUniversity of TorontoRan2021 to 2022Enrolled18ConditionsBreast Cancer, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage IIIArmsYoga Intervention
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 7 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  6. Psychostimulants for cancer-related cognitive impairment in adult cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  7. Cognitive rehabilitation for cancer-related cognitive dysfunction: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  8. Trial
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  12. Nicotinic treatment of post-chemotherapy subjective cognitive impairment: a pilot study.Journal of cancer survivorship : research and practice · 2019
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Michelle C JanelsinsUniversity of Rochester Medical Center, Rochester, NY, USA Wilmot Cancer Institute, Rochester, NY, USA Michelle_janelsins@urmc.rochester.edu.
Luke J PepponeUniversity of Rochester Medical Center, Rochester, NY, USA Wilmot Cancer Institute, Rochester, NY, USA.
Charles E HecklerUniversity of Rochester Medical Center, Rochester, NY, USA Wilmot Cancer Institute, Rochester, NY, USA.
Shelli R KeslerMD Anderson Cancer Center, Houston, TX, USA.
Lisa K SprodUniversity of Wilmington, Wilmington, NC, USA.
James AtkinsSoutheast Clinical Oncology Research Consortium NCORP, Winston-Salem, NC, USA.
Marianne MelnikCancer Research Consortium of West Michigan NCORP, Grand Rapids, MI, USA.
Charles KamenUniversity of Rochester Medical Center, Rochester, NY, USA Wilmot Cancer Institute, Rochester, NY, USA.
Jeffrey GiguereGreenville Health System NCORP, Greenville, SC, USA.
Michael J MessinoSoutheast Clinical Oncology Research Consortium NCORP, Winston-Salem, NC, USA.
Supriya G MohileUniversity of Rochester Medical Center, Rochester, NY, USA Wilmot Cancer Institute, Rochester, NY, USA.
Karen M MustianUniversity of Rochester Medical Center, Rochester, NY, USA Wilmot Cancer Institute, Rochester, NY, USA.
University of Rochester Medical Center · USSoutheast Clinical Oncology Research Consortium · USMichigan Cancer Research Consortium · USPrisma Health · USThe University of Texas MD Anderson Cancer Center · USUniversity of North Carolina Wilmington · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
UNIVERSITY OF ROCHESTER--CCOP RESEARCH BASEU10CA037420 · NCI · UNIVERSITY OF ROCHESTER · PI MORROW, GARY R · 1985 to 2014
$21.1M
Clinical and Translational Approaches to Cognitive Impairments in CancerDP2CA195765 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C · 2014 to 2014
$2.3M
Exercise Intervention for Lesbian, Gay, Bisexual, and Transgender Cancer SurvivorsK07CA190529 · NCI · UNIVERSITY OF ROCHESTER · PI KAMEN, CHARLES STEWART · 2015 to 2019
$830k
Interventions Targeting Inflammation for Chemotherapy-Related Cognitive ProblemsK07CA168886 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C · 2013 to 2017
$724k
Management of Cancer-Treatment-Induced Bone LossK07CA168911 · NCI · UNIVERSITY OF ROCHESTER · PI PEPPONE, LUKE JOSEPH · 2013 to 2017
$724k
NCI NIH HHS DP2 CA195765NCI NIH HHS K07 CA168886NCI NIH HHS K07 CA168911NCI NIH HHS K07 CA190529NCI NIH HHS U10 CA037420NCI NIH HHS UG1 CA189961
6 · The paper itself

Abstract

unlabelledBackground Interventions are needed to alleviate memory difficulty in cancer survivors. We previously showed in a phase III randomized clinical trial that YOCAS©® yoga-a program that consists of breathing exercises, postures, and meditation-significantly improved sleep quality in cancer survivors. This study assessed the effects of YOCAS©® on memory and identified relationships between memory and sleep. STUDY DESIGN AND

methodsSurvivors were randomized to standard care (SC) or SC with YOCAS©® . 328 participants who provided data on the memory difficulty item of the MD Anderson Symptom Inventory are included. Sleep quality was measured using the Pittsburgh Sleep Quality Index. General linear modeling (GLM) determined the group effect of YOCAS©® on memory difficulty compared with SC. GLM also determined moderation of baseline memory difficulty on postintervention sleep and vice versa. Path modeling assessed the mediating effects of changes in memory difficulty on YOCAS©® changes in sleep and vice versa.

resultsYOCAS©® significantly reduced memory difficulty at postintervention compared with SC (mean change: yoga=-0.60; SC=-0.16; P<.05). Baseline memory difficulty did not moderate the effects of postintervention sleep quality in YOCAS©® compared with SC. Baseline sleep quality did moderate the effects of postintervention memory difficulty in YOCAS©® compared with SC (P<.05). Changes in sleep quality was a significant mediator of reduced memory difficulty in YOCAS©® compared with SC (P<.05); however, changes in memory difficulty did not significantly mediate improved sleep quality in YOCAS©® compared with SC.

conclusionsIn this large nationwide trial, YOCAS©® yoga significantly reduced patient-reported memory difficulty in cancer survivors.

Indexed as

AdultAgedFemaleHumansMaleMeditationMemoryMiddle AgedNeoplasmsQuality of LifeSelf ReportSleepSurvivorsYogacancer-related cognitive impairmentcancer survivor“chemobrain”memory difficultyquality of lifeyoga

Identifiers

PMID26621521
PMCPMC4884662
OpenAlexW2188025202

What Socratic holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.