ReviewEndocrine2016
Exercise and diabetes: relevance and causes for response variability.
Review in Endocrine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07180446 (Predicting Exercise-Induced Insulin Sensitivity With AI), which is not on this map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predicting Exercise-Induced Insulin Sensitivity With AI: Butyrate Supplementation as a Therapy for Exercise-Resistant Individuals
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Whether or Not the Effects ofNutrients · 2020Pooled it
- Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity.Nature communications · 2020Pooled it
- Comparative Effectiveness of High-Intensity Interval Training and Moderate-Intensity Continuous Training for Cardiometabolic Risk Factors and Cardiorespiratory Fitness in Childhood Obesity: A Meta-Analysis of Randomized Controlled Trials.Frontiers in physiology · 2020Pooled it
- Exercise-induced improvement of glycemic fluctuation and its relationship with fat and muscle distribution in type 2 diabetes.Journal of diabetes · 2024Trial
- Exercise-Induced Improvements in Postprandial Glucose Response Are Blunted by Pre-Exercise Hyperglycemia: A Randomized Crossover Trial in Healthy Individuals.Frontiers in endocrinology · 2020Trial
- Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults.Frontiers in endocrinology · 2020Trial
- Trial
- The impact of maximal fat oxidation intensity exercise on glucose and lipid metabolism in individuals with overweight or obesity: A systematic review and meta-analysis.Biology of sport · 2026Review
- Branched-chain amino acid metabolism: Pathophysiological mechanism and therapeutic intervention in metabolic diseases.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Mechanisms underlying alterations of the gut microbiota by exercise and their role in shaping ecological resilience.FEMS microbiology reviews · 2025Review
- Gut Microbiota in the Progression of Type 2 Diabetes and the Potential Role of Exercise: A Critical Review.Life (Basel, Switzerland) · 2024Review
- Intra-Individual Variations in How Insulin Sensitivity Responds to Long-Term Exercise: Predictions by Machine Learning Based on Large-Scale Serum Proteomics.Metabolites · 2024Article
- Mechanisms of exercise intervention in type 2 diabetes: a bibliometric and visualization analysis based on CiteSpace.Frontiers in endocrinology · 2024Review
- A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes.Cell reports. Medicine · 2023Article
- Optimization of nutritional strategies using a mechanistic computational model in prediabetes: Application to the J-DOIT1 study data.PloS one · 2023Article
- Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes.NPJ digital medicine · 2022Article
- Regular exercise and patterns of response across multiple cardiometabolic traits: the HERITAGE family study.British journal of sports medicine · 2022Article
- Article
- Exercise-induced changes in climbing performance.Royal Society open science · 2021Article
- Functional Role of miR-155 in the Pathogenesis of Diabetes Mellitus and Its Complications.Non-coding RNA · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise as a key prevention strategy for diabetes and obesity is commonly accepted and recommended throughout the world. Unfortunately, not all individuals profit to the same extent, some exhibit exercise resistance. This phenomenon of non-response to exercise is found for several endpoints, including glucose tolerance and insulin sensitivity. Since these non-responders are of notable quantity, there is the need to understand the underlying mechanisms and to identify predictors of response. This displays the basis to develop personalized training intervention regimes. In this review, we summarize the current knowledge on response variability, with focus on human studies and improvement of glucose homeostasis as outcome.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.