ReviewAnnals of the New York Academy of Sciences2016
Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span.
Review in Annals of the New York Academy of Sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Article
- DynamicJournal of the American Chemical Society · 2025Article
- Amino acid restriction, aging, and longevity: an update.Frontiers in aging · 2024Review
- Metabolism and the Epigenome: A Dynamic Relationship.Trends in biochemical sciences · 2020Review
- Article
- Does Diet Have a Role in the Treatment of Alzheimer's Disease?Frontiers in aging neuroscience · 2020Review
- Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity.Antioxidants & redox signaling · 2018Article
- Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation.Annals of the New York Academy of Sciences · 2018Article
- Cutting back on the essentials: Can manipulating intake of specific amino acids modulate health and lifespan?Ageing research reviews · 2017Review
- Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome.Frontiers in aging neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Interventions that improve health are often associated with longevity. Reduced growth hormone signaling has been shown to increase life span in mice by over 50%. Similarly, reductions in dietary intake of methionine, in rats and mice, result in life-span extension. Many factors affect metabolic health, mitochondrial function, and resistance to stressors, each of which influence aging and life span. This paper presents a comparison of these two interventions, as well as the results of a study combining these interventions, to understand potential mechanisms underlying their effectiveness in enhancing healthy aging.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.