ArticlePharmacognosy magazine2015
Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin-induced diabetes mellitus in experimental animals.
Article in Pharmacognosy magazine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 57 citations in OpenAlex.
- Nutritional implications of olives and sugar: attenuation of post-prandial glucose spikes in healthy volunteers by inhibition of sucrose hydrolysis and glucose transport by oleuropein.European journal of nutrition · 2019Trial
- A Comprehensive Review of Moroccan Medicinal Plants for Diabetes Management.Diseases (Basel, Switzerland) · 2024Review
- Understanding the Mechanism Underlie the Antidiabetic Activity of Oleuropein UsingReports of biochemistry & molecular biology · 2022Article
- Article
- Oleuropein Improves Cognitive Dysfunction and Neuroinflammation in Diabetic Rats through the PI3K/Akt/mTOR Pathway.Applied bionics and biomechanics · 2022Article
- Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure.Drug design, development and therapy · 2021Review
- Diet to Reduce the Metabolic Syndrome Associated with Menopause. The Logic for Olive Oil.Nutrients · 2020Review
- Role of Oxidative Stress, MAPKinase and Apoptosis Pathways in the Protective Effects of Thymoquinone Against Acrylamide-Induced Central Nervous System Toxicity in Rat.Neurochemical research · 2020Article
- Effect of Caesalpinia bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway.Oxidative medicine and cellular longevity · 2020Article
- Antidiabetic activity enhancement in streptozotocin + nicotinamide-induced diabetic rats through combinational polymeric nanoformulation.International journal of nanomedicine · 2019Article
- GLP-1 mediates the modulating effect of thymoquinone on feeding behaviors in diabetic rats.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- The effects of natural nano-sized clinoptilolite andBioImpacts : BI · 2019Article
- Therapeutic potential of thymoquinone liposomes against the systemic infection of Candida albicans in diabetic mice.PloS one · 2018Article
- Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin-Induced Diabetes in Sprague-Dawley Rats.Journal of diabetes research · 2018Article
- Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus.Frontiers in pharmacology · 2018Review
- Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans.International journal of molecular sciences · 2016Review
- PROTECTIVE EFFECT OFActa endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus is one of the most important diseases related with endocrines. Its main manifestation includes abnormal metabolism of carbohydrates and lipids and inappropriate hyperglycemia that is caused by absolute or relative insulin deficiency. It affects humankind worldwide.
objectivesOur research was aimed to observe antihyperglycemic activity of thymoquinone and oleuropein. MATERIALS AND
methodsIn this study, rats were divided into six groups, 6 rats in each. Diabetes was inducted by streptozotocin (STZ). The level of fasting blood glucose was determined for each rats during the experiment, doses of thymoquinone and oleuropein (3 mg/kg and 5 mg/kg) for both, were injected intraperitoneal. Pancreatic tissues were investigated to compare β-cells in diabetic and treated rats. RESULT AND
conclusionIt was found that thymoquinone and oleuropein significantly decrease serum Glucose levels in STZ induced diabetic rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.