ArticleThe American journal of clinical nutrition2016
Is there a causal role for homocysteine concentration in blood pressure? A Mendelian randomization study.
Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.PloS one · 2017Pooled it
- Trial
- Common Methylenetetrahydrofolate Reductase PolymorphismDiagnostics (Basel, Switzerland) · 2025Article
- Effect of plasma homocysteine on cardiometabolic multimorbidity among Chinese adults: a population-based and real-world evidence study.Frontiers in nutrition · 2024Article
- Association Between Plasma Homocysteine Level and Mortality: A Mendelian Randomization Study.Korean circulation journal · 2023Article
- Plasma homocysteine levels and risk of congestive heart failure or cardiomyopathy: A Mendelian randomization study.Frontiers in cardiovascular medicine · 2023Article
- Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China.BMJ open · 2021Article
- Exploration of the risk factors of essential hypertension with hyperhomocysteinemia: A hospital-based study and nomogram analysis.Clinics (Sao Paulo, Brazil) · 2021Article
- Hypertension-Mediated Organ Damage Correlates With Serum Homocysteine Level in Community-Dwelling Elderly Chinese: The North Shanghai Study.Frontiers in cardiovascular medicine · 2021Article
- Association between plasma levels of homocysteine, folate, and vitamin BScientific reports · 2020Article
- Genetic Epidemiology in Latin America: Identifying Strong Genetic Proxies for Complex Disease Risk Factors.Genes · 2020Article
- Homocysteine and IgA nephropathy: observational and Mendelian randomization analyses.Chinese medical journal · 2020Observational
- Discovery of potential plasma protein biomarkers for acute myocardial infarction via proteomics.Journal of thoracic disease · 2019Article
- Association between plasma homocysteine and hypertension: Results from a cross-sectional and longitudinal analysis in Beijing's adult population from 2012 to 2017.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- EPIGEN-Brazil Initiative resources: a Latin American imputation panel and the Scientific Workflow.Genome research · 2018Article
- Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets.British journal of pharmacology · 2018Review
- Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: A one-carbon metabolism candidate gene study.Environment international · 2018Article
- Metabolic Profiling of Adiponectin Levels in Adults: Mendelian Randomization Analysis.Circulation. Cardiovascular genetics · 2017Article
- Red cell distribution width and homocysteine act as independent risk factors for cardiovascular events in newly diagnostic essential hypertension.Oncotarget · 2017Article
- Associations of plasma homocysteine levels with peripheral systolic blood pressure and noninvasive central systolic blood pressure in a community-based Chinese population.Scientific reports · 2017Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundAn understanding of whether homocysteine is a cause or a marker of increased blood pressure is relevant because blood homocysteine can be effectively lowered by safe and inexpensive interventions (e.g., vitamin B-6, B-9, and B-12 supplementation).
objectiveThe aim was to assess the causal influence of homocysteine on systolic and diastolic blood pressure (SBP and DBP, respectively) in adults with the use of Mendelian randomization (MR).
designData from the 1982 Pelotas Birth Cohort (Brazil) were used. A total of 4297 subjects were evaluated in 2004-2005 (mean age: 22.8 y). The association of homocysteine concentration with SBP and DBP was assessed by conventional ordinary least-squares (OLS) linear regression and 2-stage least-squares (2SLS) regression (MR analysis). The single nucleotide polymorphism (SNP) methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) was used as proxy for homocysteine concentration. We also applied MR to data from the International Consortium for Blood Pressure (ICBP) genomewide association studies (>69,000 participants) using rs1801133 and additional homocysteine-associated SNPs as instruments.
resultsIn OLS regression, a 1-SD unit increase in log homocysteine concentration was associated with an increase of 0.9 (95% CI: 0.4, 1.4) mm Hg in SBP and of 1.0 (95% CI: 0.6, 1.4) mm Hg in DBP. In 2SLS regression, for the same increase in homocysteine, the coefficients were -1.8 mm Hg for SBP (95% CI: -3.9, 0.4 mm Hg; P = 0.01) and 0.1 mm Hg for DBP (95% CI: -1.5, 1.7 mm Hg; P = 0.24). In the MR analysis of ICBP data, homocysteine concentration was not associated with SBP (β = 0.6 mm Hg for each 1-SD unit increase in log homocysteine; 95% CI: -0.8, 1.9 mm Hg) but was positively associated with DBP (β = 1.1 mm Hg; 95% CI: 0.2, 1.9 mm Hg). The association of genetically increased homocysteine with DBP was not consistent across different SNPs.
conclusionOverall, the present findings do not corroborate the hypothesis that homocysteine has a causal role in blood pressure, especially in SBP.
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