Evidence map›Paper›PMID 26678300›Full record

ArticleScientific reports2015

Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo.

Jiawen Li, Teng Ma, Dilbahar Mohar, Earl Steward, Mingyue Yu, Zhonglie Piao, Youmin He, K Kirk Shung, Qifa Zhou, Pranav M Patel and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  12. Highly Integrated Guidewire Ultrasound Imaging System-on-a-Chip.IEEE journal of solid-state circuits · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiawen LiBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Rd. Irvine, CA 92617, USA.
Teng MaNIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, CA 90089, USA.
Dilbahar MoharSchool of Medicine, University of California, Irvine, 101 The City Drive South, Orange, CA, 92868, USA.
Earl StewardSchool of Medicine, University of California, Irvine, 101 The City Drive South, Orange, CA, 92868, USA.
Mingyue YuNIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, CA 90089, USA.
Zhonglie PiaoBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Rd. Irvine, CA 92617, USA.
Youmin HeBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Rd. Irvine, CA 92617, USA.
K Kirk ShungNIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, CA 90089, USA.
Qifa ZhouNIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, CA 90089, USA.
Pranav M PatelSchool of Medicine, University of California, Irvine, 101 The City Drive South, Orange, CA, 92868, USA.
Zhongping ChenBeckman Laser Institute, University of California, Irvine, 1002 Health Sciences Rd. Irvine, CA 92617, USA.

Funding

A Resource on Medical Ultrasonic Transducer TechnologyP41EB002182 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHUNG, K KIRK · 2003 to 2016
$13.3M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
Modeling the Pediatric Upper Airway using A-OCT and Computational Fluid DynamicsR01HL105215 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ELGHOBASHI, SAID E. · 2010 to 2013
$3.7M
Combined OCT/US/PAT system for intravascular ImagingR01HL127271 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, PATEL, PRANAV · 2015 to 2018
$2.7M
Elastographic Imaging of the Retina/Choroid in Age-Related Macular DegenerationR01EY021529 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHEN, ZHONGPING, SILVERMAN, RONALD H · 2012 to 2015
$1.4M
NEI NIH HHS R01 EY021529NEI NIH HHS R01-EY-021529NHLBI NIH HHS R01 HL105215NHLBI NIH HHS R01-HL-105215NHLBI NIH HHS R01 HL125084NHLBI NIH HHS R01-HL-125084NHLBI NIH HHS R01 HL127271NHLBI NIH HHS R01-HL-127271NIBIB NIH HHS P41 EB002182NIBIB NIH HHS P41-EB002182NIBIB NIH HHS P41 EB015890NIBIB NIH HHS P41-EB-015890
6 · The paper itself

Abstract

Atherosclerotic coronary artery disease (CAD) is the number one cause of death worldwide. The majority of CAD-induced deaths are due to the rupture of vulnerable plaques. Accurate assessment of plaques is crucial to optimize treatment and prevent death in patients with CAD. Current diagnostic techniques are often limited by either spatial resolution or penetration depth. Several studies have proved that the combined use of optical and ultrasonic imaging techniques increase diagnostic accuracy of vulnerable plaques. Here, we introduce an ultrafast optical-ultrasonic dual-modality imaging system and flexible miniaturized catheter, which enables the translation of this technology into clinical practice. This system can perform simultaneous optical coherence tomography (OCT)-intravascular ultrasound (IVUS) imaging at 72 frames per second safely in vivo, i.e., visualizing a 72 mm-long artery in 4 seconds. Results obtained in atherosclerotic rabbits in vivo and human coronary artery segments show that this ultrafast technique can rapidly provide volumetric mapping of plaques and clearly identify vulnerable plaques. By providing ultrafast imaging of arteries with high resolution and deep penetration depth simultaneously, this hybrid IVUS-OCT technology opens new and safe opportunities to evaluate in real-time the risk posed by plaques, detect vulnerable plaques, and optimize treatment decisions.

Indexed as

CathetersAnimalsAorta, AbdominalCoronary Artery DiseaseCoronary VesselsHumansMiniaturizationPlaque, AtheroscleroticRabbitsRadiographySignal-To-Noise RatioTomography, Optical CoherenceUltrasonography, Interventional

Identifiers

PMID26678300
PMCPMC4683418

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.