Insulin × cardiovascular events

TrialDiabetes care2016

Cardiovascular and Other Outcomes Postintervention With Insulin Glargine and Omega-3 Fatty Acids (ORIGINALE).

ORIGIN Trial InvestigatorsPubMed ↗Publisher ↗

What the trial testedas reported · 12,537 people · 2016

Range includes no effect

No clear effect on cardiovascular events

+1%−6% to +10%

Smaller than almost all for cardiovascular events

As reported

HR 1.01, 95% CI 0.94–1.10

One number in the abstract

the abstract, start to end

(1,185 vs. 1,165 events; hazard ratio 1.01 [95% CI 0.94-1.10]; P = 0.72);

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
HR 1.010.94–1.10
Other lipid agentsInsulinCardiovascular events

Insulin × cardiovascular eventshelps?no deciding trial

unlikelylikely
0.25only evidence
1 / 4

28 papers cite it

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Full record →Abstract, authors, funding and every citing paper · PMID 26681720