Evidence map›Paper›PMID 26692008›Full record

ArticleClinical drug investigation2016

The Management of Diabetes Mellitus in Patients with Chronic Kidney Disease: A Population-Based Study in Southern Italy.

Gianluca Trifirò, Fabrizio Parrino, Valeria Pizzimenti, Francesco Giorgianni, Janet Sultana, Marco Muscianisi, Chiara Troncone, Daniele U Tari, Vincenzo Arcoraci, Domenico Santoro and 3 more

Abstract read
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In one paragraph

Article in Clinical drug investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Challenges in the Prevention and Management of Diabetic Kidney Diseases.Frontiers in clinical diabetes and healthcare · 2021
    Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Gianluca TrifiròDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy. trifirog@unime.it.
Fabrizio ParrinoPharmacology Section, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
Valeria PizzimentiPharmacology Section, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
Francesco GiorgianniPharmacology Section, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
Janet SultanaPharmacology Section, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
Marco MuscianisiPharmacology Section, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
Chiara TronconeCaserta-Local Health Service, Caserta, Italy.
Daniele U TariCaserta-Local Health Service, Caserta, Italy.
Vincenzo ArcoraciPharmacology Section, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
Domenico SantoroPharmacology Section, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
Giusi RussoPharmacology Section, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
Viviana LacavaPharmacology Section, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
Achille P CaputiDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, Department of Clinical and Experimental Medicine, Policlinico Universitario G. Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesDiabetes mellitus in patients with chronic kidney disease (CKD) is known as diabetic kidney disease (DKD). Pharmacological management of DKD is challenging due to reduced renal excretion of some antidiabetic drugs. The aim of this population-based study was to explore antidiabetic drug use in DKD patients from Southern Italy.

methodsThe Arianna database from Caserta Local Health Unit was used. Diabetic patients with incident CKD [first diagnosis date: index date (ID)] were identified by searching for specific ICD9-CM codes among hospital discharge diagnoses/procedures and/or indication of use associated with drug prescriptions. To evaluate any change in the use of antidiabetic drugs after the CKD diagnosis, the prevalence of antidiabetic drug use among DKD patients was calculated within 1 year prior to/after ID and after dialysis entry. A Kaplan-Meier analysis was used to assess the time to discontinuation of antidiabetic drugs after CKD diagnosis. The frequency of antidiabetic drugs contraindicated in renal disease in DKD patients was measured.

resultsOverall, 725 diabetic patients (mean age 72.8 ± 11.4 years) had incident CKD from 2006 to 2011. The use of combination antidiabetic drugs, biguanides and sulphonamides decreased by approximately 10, 7 and 5%, respectively, after the ID. The use of insulins increased by 10% after the ID and by 20% after entry into dialysis. The use of antidiabetic drugs not contraindicated in CKD decreased marginally after the diagnosis of CKD.

conclusionIn a general practice of Southern Italy the management of diabetes mellitus changed only marginally in newly diagnosed CKD patients, suggesting a therapeutic inertia on the part of prescribers.

Indexed as

AdultAgedAged, 80 and overDiabetic NephropathiesFemaleHumansHypoglycemic AgentsInsulinItalyKaplan-Meier EstimateMaleMiddle AgedPrevalenceRenal Insufficiency, ChronicRetrospective StudiesHypoglycemic AgentsInsulin

Identifiers

PMID26692008
OpenAlexW2259880569

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.