ArticleAmerican journal of physiology. Heart and circulatory physiology2016
Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation.
Article in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Skeletal muscle microvascular hemodynamic responses during hyperinsulinemic-euglycemic clamp in a Zucker Diabetic Sprague Dawley rat model of type 2 diabetes.Frontiers in physiology · 2025Article
- Thromboxane-induced cerebral microvascular rarefaction predicts depressive symptom emergence in metabolic disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The development of peripheral microvasculopathy with chronic metabolic disease in obese Zucker rats: a retrograde emergence?American journal of physiology. Heart and circulatory physiology · 2022Article
- Preserved β-adrenergic-mediated vasodilation in skeletal muscle of young adults with obesity despite shifts in cyclooxygenase and nitric oxide synthase.American journal of physiology. Heart and circulatory physiology · 2022Article
- Article
- Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Skeletal muscle performance in metabolic disease: Microvascular or mitochondrial limitation or both?Microcirculation (New York, N.Y. : 1994) · 2019Review
- Type 2 diabetes mellitus in the Goto-Kakizaki rat impairs microvascular function and contributes to premature skeletal muscle fatigue.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Chronic atorvastatin and exercise can partially reverse established skeletal muscle microvasculopathy in metabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2018Article
- Protection from vascular dysfunction in female rats with chronic stress and depressive symptoms.American journal of physiology. Heart and circulatory physiology · 2018Article
- Role of Chronic Stress and Exercise on Microvascular Function in Metabolic Syndrome.Medicine and science in sports and exercise · 2018Article
- Diabetes, cardiovascular disease and the microcirculation.Cardiovascular diabetology · 2018Review
- Beneficial Pleiotropic Antidepressive Effects of Cardiovascular Disease Risk Factor Interventions in the Metabolic Syndrome.Journal of the American Heart Association · 2018Article
- Inhalation exposure to three-dimensional printer emissions stimulates acute hypertension and microvascular dysfunction.Toxicology and applied pharmacology · 2017Article
- Altered post-capillary and collecting venular reactivity in skeletal muscle with metabolic syndrome.The Journal of physiology · 2017Article
- Cardiovascular consequences of metabolic syndrome.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Impaired Tissue Oxygenation in Metabolic Syndrome Requires Increased Microvascular Perfusion Heterogeneity.Journal of cardiovascular translational research · 2017Article
- Altered distribution of adrenergic constrictor responses contributes to skeletal muscle perfusion abnormalities in metabolic syndrome.Microcirculation (New York, N.Y. : 1994) · 2017Article
- Peripheral Blood Flow Regulation in Human Obesity and Metabolic Syndrome.Exercise and sport sciences reviews · 2016Review
- Clinical and functional variables can predict general fatigue in patients with acromegaly: an explanatory model approach.Archives of endocrinology and metabolismArticle
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
To determine the impact of progressive elevations in peripheral vascular disease (PVD) risk on microvascular function, we utilized eight rat models spanning "healthy" to "high PVD risk" and used a multiscale approach to interrogate microvascular function and outcomes: healthy: Sprague-Dawley rats (SDR) and lean Zucker rats (LZR); mild risk: SDR on high-salt diet (HSD) and SDR on high-fructose diet (HFD); moderate risk: reduced renal mass-hypertensive rats (RRM) and spontaneously hypertensive rats (SHR); high risk: obese Zucker rats (OZR) and Dahl salt-sensitive rats (DSS). Vascular reactivity and biochemical analyses demonstrated that even mild elevations in PVD risk severely attenuated nitric oxide (NO) bioavailability and caused progressive shifts in arachidonic acid metabolism, increasing thromboxane A2 levels. With the introduction of hypertension, arteriolar myogenic activation and adrenergic constriction were increased. However, while functional hyperemia and fatigue resistance of in situ skeletal muscle were not impacted with mild or moderate PVD risk, blood oxygen handling suggested an increasingly heterogeneous perfusion within resting and contracting skeletal muscle. Analysis of in situ networks demonstrated an increasingly stable and heterogeneous distribution of perfusion at arteriolar bifurcations with elevated PVD risk, a phenomenon that was manifested first in the distal microcirculation and evolved proximally with increasing risk. The increased perfusion distribution heterogeneity and loss of flexibility throughout the microvascular network, the result of the combined effects on NO bioavailability, arachidonic acid metabolism, myogenic activation, and adrenergic constriction, may represent the most accurate predictor of the skeletal muscle microvasculopathy and poor health outcomes associated with chronic elevations in PVD risk.
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