DPP-4 inhibitors × adverse events & safety

SynthesisEndocrine2016

Systematic review and meta-analysis of vildagliptin for treatment of type 2 diabetes.

Eleni Bekiari et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 28,006 people · 2016

Randomised comparison

Lowered hypoglycaemia

−0.69percentage points−0.83 to −0.56

As reported

difference −0.69 %, 95% CI −0.83 to −0.56

Randomised comparison

Lowered hypoglycaemia

−81%−85% to −76%

Bigger than almost all on the map

As reported

OR 0.19, 95% CI 0.15–0.24

Range includes no effect

No clear effect on adverse events & safety

0.4× to 2.5×

Bigger than 1 in 10 for adverse events & safety

As reported

OR 0.97, 95% CI 0.37–2.53

Range includes no effect

No clear effect on hypoglycaemia

−17%−41% to +16%

Bigger than 4 in 10 on the map

As reported

OR 0.83, 95% CI 0.59–1.16

+2 more in the walkthrough ↓

Six numbers in the abstract

the abstract, start to end

HbA1c (weighted mean difference WMD -0.69 %; 95 % CI -0.83 to -0.56 %; I (2) = 82 %), and it was as effective as other antidiabetic agents (WMD -0.01 %; 95 % CI -0.16 to 0.14 %; I (2) = 93 %), without increasing the risk for hypoglycemia (OR 0.83; 95 % CI 0.59 to 1.16; I (2) = 0 % vs. placebo, and OR 0.19; 95 % CI 0.15 to 0.24; I (2) =

the incidence of pancreatitis (OR 0.97; 95 % CI 0.37 to 2.53; I (2) = 0 %), serious adverse events (OR 0.98; 95 % CI 0.88 to 1.09; I (2) = 0 %) or death (OR 1.10, 95 % CI 0.75 to 1.61; I (2) =

← favours treatmentfavours comparator →
could be chance
Hypoglycaemia
−0.69−0.83 to −0.56
Adverse events & safety
OR 0.970.37–2.53
Hypoglycaemia
OR 0.830.59–1.16
Adverse events & safety
OR 0.980.88–1.09
Adverse events & safety
OR 1.100.75–1.61
Hypoglycaemia
OR 0.190.15–0.24
DPP-4 inhibitorsOther glucose-loweringAdverse events & safetyHypoglycaemia

DPP-4 inhibitors × adverse events & safetyharms?mixed

unlikelylikely
0.00not counted
← favours comparatorfavours treatment →
more certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 26714458