ArticleMedical physics2016
The impact of system matrix dimension on small FOV SPECT reconstruction with truncated projections.
Article in Medical physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 23 citations in OpenAlex.
- Accurate CT-free correction of attenuation, scatter, and aperture effects using deep learning in dedicated cardiac pinhole SPECT.Annals of nuclear medicine · 2026Article
- A generalizable diffusion framework for 3D low-dose and few-view cardiac SPECT imaging.Medical image analysis · 2025Article
- DuDoCFNet: Dual-Domain Coarse-to-Fine Progressive Network for Simultaneous Denoising, Limited-View Reconstruction, and Attenuation Correction of Cardiac SPECT.IEEE transactions on medical imaging · 2024Article
- Direct and indirect strategies of deep-learning-based attenuation correction for general purpose and dedicated cardiac SPECT.European journal of nuclear medicine and molecular imaging · 2022Article
- SPECTnet: a deep learning neural network for SPECT image reconstruction.Annals of translational medicine · 2021Article
- Best practice for the nuclear medicine technologist in CT-based attenuation correction and calcium score for nuclear cardiology.European journal of hybrid imaging · 2020Review
- Direct List Mode Parametric Reconstruction for Dynamic Cardiac SPECT.IEEE transactions on medical imaging · 2020Article
- Performance analysis of a high-sensitivity multi-pinhole cardiac SPECT system with hemi-ellipsoid detectors.Medical physics · 2019Article
- Quantification of intramyocardial blood volume withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Application of the 4-D XCAT Phantoms in Biomedical Imaging and Beyond.IEEE transactions on medical imaging · 2018Review
- Noise suppressed partial volume correction for cardiac SPECT/CT.Medical physics · 2016Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeA dedicated cardiac hybrid single photon emission computed tomography (SPECT)/CT scanner that uses cadmium zinc telluride detectors and multiple pinhole collimators for stationary acquisition offers many advantages. However, the impact of the reconstruction system matrix (SM) dimension on the reconstructed image quality from truncated projections and 19 angular samples acquired on this scanner has not been extensively investigated. In this study, the authors aimed to investigate the impact of the dimensions of SM and the use of body contour derived from adjunctive CT imaging as an object support in reconstruction on this scanner, in relation to background extracardiac activity.
methodsThe authors first simulated a generic SPECT/CT system to image four NCAT phantoms with various levels of extracardiac activity and compared the reconstructions using SM in different dimensions and with/without body contour as a support for quantitative evaluations. The authors then compared the reconstructions of 18 patient studies, which were acquired on a GE Discovery NM570c scanner following injection of different radiotracers, including (99m)Tc-Tetrofosmin and (123)I-mIBG, comparing the scanner's default SM that incompletely covers the body with a large SM that incorporates a patient specific full body contour.
resultsThe simulation studies showed that the reconstructions using a SM that only partially covers the body yielded artifacts on the edge of the field of view (FOV), overestimation of activity and increased nonuniformity in the blood pool for the phantoms with higher relative levels of extracardiac activity. However, the impact on the quantitative accuracy in the high activity region, such as the myocardium, was subtle. On the other hand, an excessively large SM that enclosed the entire body alleviated the artifacts and reduced overestimation in the blood pool, but yielded slight underestimation in myocardium and defect regions. The reconstruction using the larger SM with body contour yielded the most quantitatively accurate results in all the regions of interest for a range of uptake levels in the extracardiac regions. In patient studies, the SM incorporating patient specific body contour minimized extracardiac artifacts, yielded similar myocardial activity, lower blood pool activity, and subsequently improved myocardium-to-blood pool contrast (p < 0.0001) by an average of 7% (range 0%-18%) across all the patients, compared to the reconstructions using the scanner's default SM.
conclusionsTheir results demonstrate that using a large SM that incorporates a CT derived body contour in the reconstruction could improve quantitative accuracy within the FOV for clinical studies with high extracardiac activity.
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