Evidence map›Paper›PMID 26749341›Full record

ArticleInternational journal of clinical pharmacy2016

Exploring the relationship between fall risk-increasing drugs and fall-related fractures.

Sabrina De Winter, Sarah Vanwynsberghe, Veerle Foulon, Eddy Dejaeger, Johan Flamaing, An Sermon, Lorenz Van der Linden, Isabel Spriet

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Article in International journal of clinical pharmacy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sabrina De WinterClinical Pharmacology and Pharmacotherapy, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium. sabrina.dewinter@uzleuven.be.
Sarah VanwynsbergheClinical Pharmacology and Pharmacotherapy, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.
Veerle FoulonClinical Pharmacology and Pharmacotherapy, Catholic University Leuven, Herestraat 49 - Bus 521, 3000, Louvain, Belgium.
Eddy DejaegerGerontology and Geriatrics, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.
Johan FlamaingGerontology and Geriatrics, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.
An SermonTraumatology, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.
Lorenz Van der LindenClinical Pharmacology and Pharmacotherapy, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.
Isabel SprietClinical Pharmacology and Pharmacotherapy, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHospital admissions due to fall-related fractures are a major problem in the aging population. Several risk factors have been identified, including drug use. Most studies often retrieved prescription-only drugs from national databases. These are associated with some limitations as they do not always reliably reproduce the complete patient's active drug list.

objectiveTo evaluate the association between the number of FRIDs intake identified by a standardised medication reconciliation process and a fall-related fracture leading to a hospital admission in older adults.

settingThe first cohort has been recruited from one traumatology ward of a tertiary teaching hospital in Belgium and the second cohort has been recruited from 11 community pharmacies in Belgium.

methodA prospective study with two individually matched cohorts was performed. Adult patients (≥75 years) admitted with an injury due to a fall were included in the first cohort (faller group). The second cohort consisted of patients who did not suffer from a fall within the last 6 months (non-faller group). Matching was performed for age, gender, place of residence and use of a walking aid. In both groups, clinical pharmacists and undergraduate pharmacy students obtained the medication history, using a standardised approach. A list of drugs considered to increase the risk of falling was created. It included cardiovascular drugs and drugs acting on the nervous system. A linear mixed model was used to compare the number of fall risk-increasing drugs between fallers and non-fallers.

main outcome measureThe number of fall risk-increasing drugs in a faller versus a non-faller group.

resultsSixty-one patients were matched with 121 non-fallers. Patients received on average 3.1 ± 2.1 and 3.2 ± 1.8 fall risk-increasing drugs in the faller and in the non-faller group, respectively. The mean number of fall risk-increasing drugs was comparable in both groups (p = 0.844), even after adjusting for alcohol consumption, fear of falling, vision and foot problems (p = 0.721).

conclusionIn a sample of hospitalised patients admitted for a fall-related injury, no significant difference in the number of fall risk-increasing drugs versus that of an outpatient group of non-fallers was found.

Indexed as

Accidental FallsAgedAged, 80 and overBelgiumCohort StudiesCommunity Pharmacy ServicesFemaleFractures, BoneHumansMalePatient AdmissionPrescription DrugsProspective StudiesRisk FactorsPrescription DrugsBelgiumFall risk-increasing drugsFallsFracturesHospitalisationOlder adults

Identifiers

PMID26749341

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.