Trial reportObesity surgery2016
Circulating ANGPTL8/Betatrophin Concentrations Are Increased After Surgically Induced Weight Loss, but Not After Diet-Induced Weight Loss.
Trial report in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- ANGPTL8 is upregulated in subcutaneous adipose tissue at early term after bariatric surgery in patients living with obesity.European journal of clinical investigation · 2026Article
- Role of ANGPTL8 in NAFLD Improvement after Bariatric Surgery in Experimental and Human Obesity.International journal of molecular sciences · 2021Article
- Effect of Ileal Transposition (IT) on Angiopoietin-Like Protein-8 (ANGPTL8) and Pentraxin (PTX3) Plasma Level in Sprague-Dawley Rats Fed High-Fat Diet (HFD).International journal of endocrinology · 2021Article
- The circulating ANGPTL8 levels show differences among novel subgroups of adult patients with diabetes and are associated with mortality in the subsequent 5 years.Scientific reports · 2020Article
- Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders.BMC endocrine disorders · 2020Article
- Evidences for Expression and Location of ANGPTL8 in Human Adipose Tissue.Journal of clinical medicine · 2020Article
- Angiopoietin-like 8 (ANGPTL8) expression is regulated by miR-143-3p in human hepatocytes.Gene · 2019Article
- The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity.Cardiovascular diabetology · 2018Article
- ANGPTL8: An Important Regulator in Metabolic Disorders.Frontiers in endocrinology · 2018Review
- A New Tactic for Label-Free Recognition of β-Trophin via Electrochemiluminescent Signalling on an AuNPs Supported Immuno-Interface.Scientific reports · 2017Article
- Increased circulating full-length betatrophin levels in drug-naïve metabolic syndrome.Oncotarget · 2017Article
- Cloning, expression, and spectral analysis of mouse betatrophin.Medical journal of the Islamic Republic of Iran · 2017Article
- The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking.Open biology · 2016Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundANGPTL8/betatrophin is a secreted protein reported to be involved in β-cell replication that has recently been shown to be more related to lipid metabolism. Weight loss represents a clinical situation of improvement of glucose homeostasis and overall metabolic control. The aim of the present study was to analyze the impact of weight loss induced by either a conventional dietary treatment or bariatric surgery on ANGPTL8/betatrophin concentrations.
methodsSerum concentrations of ANGPTL8/betatrophin were measured by ELISA in 158 subjects before and 1 year after weight loss induced either by conventional dietary treatment (n = 38) or bariatric surgery (sleeve gastrectomy, n = 20, or Roux-en-Y gastric bypass, n = 100).
resultsMassive surgery-induced weight loss after SG or RYGB was accompanied by a statistically significant increase in circulating levels of ANGPTL8/betatrophin (28.1 ± 13.9 to 40.3 ± 22.8 ng/mL, P = 0.001 after SG; 24.6 ± 10.9 to 41.7 ± 19.4 ng/mL, P < 0.001 after RYGB), while remaining unchanged 25.6 ± 13.3 to 25.4 ± 10.7 ng/mL (P = 0.891) after diet-induced weight loss. The change in ANGPTL8/betatrophin levels was positively correlated with the change in HDL-C concentrations.
conclusionsOur study showed that serum ANGPTL8/betatrophin concentrations were increased in obese subjects after surgically induced weight loss, but not after weight loss achieved by conventional dietary treatment. The change in ANGPTL8/betatrophin concentrations emerged as a significant predictor of the change in HDL-C levels after weight loss.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.