ArticleInternational journal of clinical and experimental medicine2015
Correlation analysis between serum lipoprotein (a) and the incidence of aortic valve sclerosis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- The role of elevated lipoprotein(a) in aortic valve disease: a systematic review.Frontiers in cardiovascular medicine · 2025Pooled it
- Age-Dependent Clinical Relevance of Lipoprotein(a): A Comprehensive Review from Childhood to Adulthood.Journal of clinical medicine · 2025Review
- Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology.Journal of lipid research · 2016Review
- Trace elements in patients with aortic valve sclerosis.Therapeutic advances in cardiovascular diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This clinical trial explores the correlation between serum lipoprotein and the severity of aortic valve sclerosis in patients diagnosed with aortic valve sclerosis (AVS). A total of 1260 subjects diagnosed with AVS were enrolled in this study between May 2005 and June 2013 and divided into the young-aged (30-59 years, n=217), middle-aged (60-74 years, n=561) and elderly groups (75-93 years, n=482). In each group, patients were sub-grouped into AVS and healthy controls according to angiography findings. Parameters including triglyceride (TG), serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), free fatty acid (FFA), lipoprotein (a) [Lp(a)], apolipoprotein A1 (ApoAl) and apolipoprotein B (ApoB) were accurately measured. Correlation between these parameters and the severity of AVS was statistically evaluated. In the middle-aged and elderly groups, serum Lp(a), TC and LDL-C were significantly higher in patients with AVS compared with healthy counterparts (both P<0.05). In the elderly group, serum HDL-C in AVS patients was significantly lower than healthy subjects (P<0.05). In the young-aged group, serum Lp(a) and ApoB were significantly increased compared with healthy counterparts (both P<0.05). Gemini score in the elderly group was significantly higher than the other groups (both P<0.01). No statistical significance was observed in Lp(a) levels among groups I, II and III. The number of coronary stenosis in group III was significantly increased than those in groups I and II (P<0.01). Lp(a), LDL-C and aging act as independent risk factors of AVS and promote the incidence and progress of AVS.
Indexed as
Identifiers
26770570PMC4694470W2252822724What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.