Evidence map›Paper›PMID 26771114›Full record

ArticleCell metabolism2016

Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes.

Adil Mardinoglu, Jan Boren, Ulf Smith

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Trial
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  8. Frontiers in nutrition · 2023
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Human Gut Microbiota in Health and Selected Cancers.International journal of molecular sciences · 2021
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Adil MardinogluScience for Life Laboratory, KTH - Royal Institute of Technology, 171 21 Stockholm, Sweden; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden. Electronic address: adilm@scilifelab.se.
Jan BorenDepartment of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
Ulf SmithDepartment of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Lundberg Laboratory for Diabetes Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes (T2D) is associated with dysbiosis of the gut microbiota, though diabetes treatment regimens, including metformin, may confound the results. Forslund et al. (2015) identify distinct disease and drug signatures and highlight the importance of adjusting for treatment when investigating how T2D influences the human gut microbiome.

Indexed as

Diabetes Mellitus, Type 2FemaleGastrointestinal MicrobiomeHumansMaleMetforminMetformin

Identifiers

PMID26771114

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.