ArticleeLife2016
Spatially coordinated dynamic gene transcription in living pituitary tissue.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Patterns of extreme outlier gene expression suggest an edge of chaos effect in transcriptomic networks.Genome biology · 2025Article
- Transcriptional bursting dynamics in gene expression.Frontiers in genetics · 2024Review
- Poisson representation: a bridge between discrete and continuous models of stochastic gene regulatory networks.Journal of the Royal Society, Interface · 2023Article
- LRLoop: a method to predict feedback loops in cell-cell communication.Bioinformatics (Oxford, England) · 2022Article
- A New Perspective on Regulation of Pituitary Plasticity: The Network of SOX2-Positive Cells May Coordinate Responses to Challenge.Endocrinology · 2022Article
- Corticotroph isolation from Pomc-eGFP mice reveals sustained transcriptional dysregulation characterising a mouse model of glucocorticoid-induced suppression of the hypothalamus-pituitary-adrenal axis.Journal of neuroendocrinology · 2022Article
- Transcription Factor Pit-1 Affects Transcriptional Timing in the Dual-Promoter Human Prolactin Gene.Endocrinology · 2021Article
- Calcium dynamics and chromatin remodelling underlie heterogeneity in prolactin transcription.Journal of molecular endocrinology · 2021Article
- Towards systems tissue engineering: Elucidating the dynamics, spatial coordination, and individual cells driving emergent behaviors.Biomaterials · 2020Review
- A Similar Speciation Process Relying on Cellular Stochasticity in Microbial and Cancer Cell Populations.iScience · 2020Review
- Multiple Myeloma as a Bone Disease? The Tissue Disruption-Induced Cell Stochasticity (TiDiS) Theory.Cancers · 2020Article
- A Mechanochemical Model of Transcriptional Bursting.Biophysical journal · 2020Article
- Multimodal transcriptional control of pattern formation in embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A Darwinian and Physical Look at Stem Cell Biology Helps Understanding the Role of Stochasticity in Development.Frontiers in cell and developmental biology · 2020Article
- Imaging and Manipulating Pituitary Function in the Awake Mouse.Endocrinology · 2019Article
- Disentangling juxtacrine from paracrine signalling in dynamic tissue.PLoS computational biology · 2019Article
- Cancer Stem Cells: From Historical Roots to a New Perspective.Journal of oncology · 2019Review
- Differences in mutational processes and intra-tumour heterogeneity between organs: The local selective filter hypothesis.Evolution, medicine, and public health · 2019Review
- Article
- Bayesian inference on stochastic gene transcription from flow cytometry data.Bioinformatics (Oxford, England) · 2018Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Transcription at individual genes in single cells is often pulsatile and stochastic. A key question emerges regarding how this behaviour contributes to tissue phenotype, but it has been a challenge to quantitatively analyse this in living cells over time, as opposed to studying snap-shots of gene expression state. We have used imaging of reporter gene expression to track transcription in living pituitary tissue. We integrated live-cell imaging data with statistical modelling for quantitative real-time estimation of the timing of switching between transcriptional states across a whole tissue. Multiple levels of transcription rate were identified, indicating that gene expression is not a simple binary 'on-off' process. Immature tissue displayed shorter durations of high-expressing states than the adult. In adult pituitary tissue, direct cell contacts involving gap junctions allowed local spatial coordination of prolactin gene expression. Our findings identify how heterogeneous transcriptional dynamics of single cells may contribute to overall tissue behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.