SynthesisNature genetics2016
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 1 pooled it
22.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
161 citing papers in PubMed, 1 synthesis or guideline pooled it, 281 citations in OpenAlex.
- Molecular Biomarker Testing for the Diagnosis of Diffuse Gliomas.Archives of pathology & laboratory medicine · 2022Guideline
- Machine learning-predicted chromatin organization landscape across pediatric tumors.Scientific reports · 2026Article
- Metabolic dependencies and neural progenitor dysregulation: driving forces in paediatric high-grade glioma development.Cancer metastasis reviews · 2026Review
- From Classical to Emerging Biomarkers of Brain and Central Nervous System Tumors. An Evidence-Based Review with a Focus on Gliomas.Cellular and molecular neurobiology · 2026Review
- RNA-binding protein quaking: a multifunctional regulator in tumour progression.Annals of medicine · 2025Review
- Pediatric diffuse low-grade glioma with oligodendroglioma-like features: A case report.Experimental and therapeutic medicine · 2025Article
- CircFAT1(e2) acts as a sponge for miR-30e-5p and inhibits glioma progression by regulating MYBL2-mediated cell proliferation.Discover oncology · 2025Article
- Role of repulsive guidance signaling and GPR180 in pediatric low-grade glioma infiltration.NPJ precision oncology · 2025Article
- Letter to the Editor: Rare case of angiocentric glioma in an adult with refractory epilepsy.Acta neurologica Belgica · 2025Article
- Illuminating radiogenomic signatures in pediatric-type diffuse gliomas: insights into molecular, clinical, and imaging correlations. Part II: low-grade group.La Radiologia medica · 2025Review
- A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas.Nature communications · 2025Article
- The malignant transformation of an atypical angiocentric glioma, MYB-altered.Acta neuropathologica communications · 2025Article
- Review
- Myelodysplastic syndrome-post cytotoxic therapy for pediatric low-grade glioma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Clinical characteristics and detection of MYB-QKI fusions in patients with angiocentric glioma.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Pediatric neuro-oncology: Highlights of the last quarter-century.Neoplasia (New York, N.Y.) · 2025Review
- Pharmacological Phase I Clinical Trials in Pediatric Brain Tumors (1990-2024): A Historical Perspective.Oncology research · 2025Review
- BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid-dendritic cell leukemia.JCI insight · 2024Article
- Extra-temporal pediatric low-grade gliomas and epilepsy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Paediatric low-grade glioma: the role of classical pathology in integrated diagnostic practice.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
101 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
62 authors at 19 institutions in 5 countries.
Pratiti BandopadhayayDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Lori A RamkissoonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Payal JainDivision of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Guillaume BergtholdDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Jeremiah WalaDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Rhamy ZeidHarvard Medical School, Boston, Massachusetts, USA.
Steven E SchumacherDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Laura UrbanskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Ryan O'RourkeDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
William J GibsonDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Kristine PeltonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Shakti H RamkissoonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Harry J HanDivision of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Yuankun ZhuDivision of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Namrata ChoudhariDivision of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Amanda SilvaDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Katie BoucherDivision of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Rosemary E HennDivision of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Yun Jee KangDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
David KnoffDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0001-6233-2893
Brenton R PaolellaDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Adrianne Gladden-YoungBroad Technology Laboratories, Broad Institute, Cambridge, Massachusetts, USA.
Pascale VarletLaboratoire de Neuropathologie, Hopital Sainte-Anne, Université Paris V Descartes, Paris, France.
Melanie PagesLaboratoire de Neuropathologie, Hopital Sainte-Anne, Université Paris V Descartes, Paris, France.
Peleg M HorowitzDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Alexander FederationHarvard Medical School, Boston, Massachusetts, USA.
Hayley MalkinDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.
Adam A TracyBroad Institute, Cambridge, Massachusetts, USA.
Sara SeepoBroad Institute, Cambridge, Massachusetts, USA.
Matthew DucarDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Paul Van HummelenCenter for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Mariarita SantiDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Anna Maria BuccolieroPathology Unit, Anna Meyer Children's University Hospital, Florence, Italy.
Mirko ScagnetNeurosurgery Unit, Anna Meyer Children's Hospital, University of Florence, Florence, Italy.
Daniel C BowersDivision of Pediatric Hematology-Oncology, University of Texas Southwestern Medical School, Dallas, Texas, USA.
Caterina GianniniDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Stephanie PugetDepartement de Neurochirurgie, Hopital Necker-Enfants Malades, Université Paris V Descartes, Paris, France.
Cynthia HawkinsDivision of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Uri TaboriDivision of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Almos KleknerDepartment of Neurosurgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
Laszlo BognarDepartment of Neurosurgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
Peter C BurgerDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Charles EberhartDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Fausto J RodriguezDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
D Ashley HillBrain Tumor Institute, Children's National Medical Center, Washington, DC, USA.
Sabine MuellerDepartment of Neurology, University of California San Francisco School of Medicine, San Francisco, California, USA.
Daphne A Haas-KoganDepartment of Neurological Surgery, University of California San Francisco School of Medicine, San Francisco, California, USA.
Joanna J PhillipsDepartment of Neurological Surgery, University of California San Francisco School of Medicine, San Francisco, California, USA.
Sandro SantagataDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Charles D StilesDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
James E BradnerBroad Institute, Cambridge, Massachusetts, USA.
Nada JabadoDivision of Experimental Medicine, Montreal Children's Hospital, McGill University and McGill University Health Centre, Montreal, Quebec, Canada.
Alon GorenBroad Technology Laboratories, Broad Institute, Cambridge, Massachusetts, USA.
Jacques GrillDepartment de Cancerologie de l'Enfant et de l'Adolescent et Unité Mixte de Recherche du Centre National de la Recherche Scientifique 8203 'Vectorologie et Nouvelles Therapeutiques du Cancer', Gustave Roussy, Université Paris XI Sud, Villejuif, France.
Azra H LigonBrigham and Women's Hospital Department of Pathology, Center for Advanced Molecular Diagnostics, Division of Cytogenetics, Boston, Massachusetts, USA.
Liliana GoumnerovaDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.
Angela J WaandersDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Phillip B StormDivision of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Mark W KieranDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.
Keith L LigonBroad Institute, Cambridge, Massachusetts, USA.
Rameen BeroukhimDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Adam C ResnickDivision of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Broad Institute · USChildren's Hospital of Philadelphia · USDana-Farber Cancer Institute · USBrigham and Women's Hospital · USHarvard University · USJohns Hopkins University · USUniversity of California, San Francisco · USHospital for Sick Children · CAMeyer Children's Hospital · ITUniversité Paris Cité · FRUniversité Paris-Saclay · FRUniversity of Debrecen · HUBoston Children's Hospital · USChildren's National · USDana-Farber/Boston Children's Cancer and Blood Disorders Center · USHôpital Necker-Enfants Malades · FRMayo Clinic · USMontreal Children's Hospital · CAThe University of Texas Southwestern Medical Center · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MTraining Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MVASCULAR, PULMONARY AND RENAL INJURYT32HL007627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIMBRONE, MICHAEL A, MITCHELL, RICHARD N · 1985 to 2019
$12.7MTherapeutic Opportunities for Pediatric AstrocytomaP01CA142536 · NCI · DANA-FARBER CANCER INST · PI LIGON, KEITH LLOYD · 2011 to 2015
$7.9MGenetic evolution of glioblastomas during radiation and temozolomide therapyR01CA188228 · NCI · DANA-FARBER CANCER INST · PI BEROUKHIM, RAMEEN, CHAKRAVARTI, ARNAB · 2015 to 2025
$6.9MPrecision Medicine For Pediatric Low-Grade GliomasR01NS091620 · NINDS · DANA-FARBER CANCER INST · PI HAAS-KOGAN, DAPHNE A., RESNICK, ADAM CAIN · 2015 to 2019
$2.6MPediatric low-grade gliomas: biology and molecular targeting.R01NS085336 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI RESNICK, ADAM CAIN · 2014 to 2018
$1.8MALK signaling in CNS development, ischemic brain injury and gliomagenesisK08NS087118 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI RAMKISSOON, SHAKTI H · 2014 to 2015
$387kCancer Specific Sensitivity to Suppression of Spliceosome ComponentsF32CA180653 · NCI · DANA-FARBER CANCER INST · PI PAOLELLA, BRENTON ROBERT · 2014 to 2017
$148kHemizygous deletion of esential genes enables a novel therqpeutic vulnerability in cancerF30CA192725 · NCI · HARVARD MEDICAL SCHOOL · PI GIBSON, WILLIAM J · 2015 to 2017
$121kNCI NIH HHS F30 CA192725NCI NIH HHS F32 CA180653NCI NIH HHS P01 CA142536NCI NIH HHS P01CA142536NCI NIH HHS R01 CA188228NHGRI NIH HHS T32 HG002295NHLBI NIH HHS T32 HL007627NIGMS NIH HHS T32 GM007753NINDS NIH HHS 1R01NS091620NINDS NIH HHS K08 NS087118NINDS NIH HHS K08NS087118NINDS NIH HHS R01 NS085336NINDS NIH HHS R01NS085336
Abstract
Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, including 19 angiocentric gliomas. We identified MYB-QKI fusions as a specific and single candidate driver event in angiocentric gliomas. In vitro and in vivo functional studies show that MYB-QKI rearrangements promote tumorigenesis through three mechanisms: MYB activation by truncation, enhancer translocation driving aberrant MYB-QKI expression and hemizygous loss of the tumor suppressor QKI. To our knowledge, this represents the first example of a single driver rearrangement simultaneously transforming cells via three genetic and epigenetic mechanisms in a tumor.
Indexed as
CarcinogenesisCell Line, TumorChildComparative Genomic HybridizationExomeGene Expression Regulation, NeoplasticGene RearrangementGliomaHigh-Throughput Nucleotide SequencingHumansMutationOncogene Proteins, FusionOncogene Proteins v-mybRNA-Binding ProteinsOncogene Proteins, FusionOncogene Proteins v-mybQKI protein, humanRNA-Binding Proteins
Identifiers
What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.