Trial reportPloS one2016
Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01112709 (Maintaining Resistance Training in Older Prediabetic Adults), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maintaining Resistance Training in Older Prediabetic Adults: Theoretical Approach
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- The role of resistance training in improving beta-cell function in type 2 diabetes: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Exercise training modalities in prediabetes: a systematic review and network meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Resist diabetes: A randomized clinical trial for resistance training maintenance in adults with prediabetes.PloS one · 2017Trial
- Validity and reliability of the health belief model questionnaire for dietary patterns and physical activity in prediabetes.Journal of education and health promotion · 2025Article
- The Effects of 24 Weeks of Non-Face-to-Face Home Exercise on Body Composition, Physical Fitness, Cardiovascular Function, and Blood Profiles in Pre-Metabolic Syndrome Korean Adults: A Pilot Study.Healthcare (Basel, Switzerland) · 2022Article
- Mechanical overload-induced muscle-derived extracellular vesicles promote adipose tissue lipolysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Type and timing of exercise during lunch breaks for suppressing postprandial increases in blood glucose levels in workers.Journal of occupational health · 2021Article
- Regression from prediabetes to normal glucose levels is more frequent than progression towards diabetes: The CRONICAS Cohort Study.Diabetes research and clinical practice · 2020Article
- The State of Diabetes in Kansas: A Community Centered Approach to the Treatment of Diverse Populations.Kansas journal of medicine · 2017Article
- Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism.Reviews in endocrine & metabolic disorders · 2016Review
- Update on the effects of physical activity on insulin sensitivity in humans.BMJ open sport & exercise medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine if prediabetes phenotype influences improvements in glucose homeostasis with resistance training (RT).
methodsOlder, overweight individuals with prediabetes (n = 159; aged 60±5 yrs; BMI 33±4 kg/m2) completed a supervised RT program twice per week for 12 weeks. Body weight and composition, strength, fasting plasma glucose, 2-hr oral glucose tolerance, and Matsuda-Defronza estimated insulin sensitivity index (ISI) were assessed before and after the intervention. Participants were categorized according to their baseline prediabetes phenotype as impaired fasting glucose only (IFG) (n = 73), impaired glucose tolerance only (IGT) (n = 21), or combined IFG and IGT (IFG/IGT) (n = 65).
resultsChest press and leg press strength increased 27% and 18%, respectively, following the 12-week RT program (both p<0.05). Waist circumference (-1.0%; pre 109.3±10.3 cm, post 108.2±10.6 cm) and body fat (-0.6%; pre 43.7±6.8%, post 43.1±6.8%) declined, and lean body mass (+1.3%; pre 52.0±10.4 kg, post 52.7±10.7 kg) increased following the intervention. Fasting glucose concentrations did not change (p>0.05) following the intervention. However, 2-hr oral glucose tolerance improved in those with IGT (pre 8.94±0.72 mmol/l, post 7.83±1.11 mmol/l, p<0.05) and IFG/IGT (pre 9.66±1.11mmol/l, post 8.60±2.00 mmol/l) but not in those with IFG (pre 6.27±1.28mmol/l, post 6.33± 1.55 mmol/l). There were no significant changes in ISI or glucose area under the curve following the RT program.
conclusionsRT without dietary intervention improves 2-hr oral glucose tolerance in individuals with prediabetes. However, the improvements in glucose homeostasis with RT appear limited to those with IGT or combined IFG and IGT.
trial registrationClinicalTrials.gov: NCT01112709.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.