Evidence map›Paper›PMID 26849202›Full record

Trial reportJournal of child and adolescent psychopharmacology2016

Magnetic Resonance Imaging-Guided, Open-Label, High-Frequency Repetitive Transcranial Magnetic Stimulation for Adolescents with Major Depressive Disorder.

Christopher A Wall, Paul E Croarkin, Mandie J Maroney-Smith, Laura M Haugen, Joshua M Baruth, Mark A Frye, Shirlene M Sampson, John D Port

2 registry-linked trialsOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of child and adolescent psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03363919 nacompletednot on this mapstarted 2018, after this paper: background citation

Glutamatergic and GABAergic Biomarkers in rTMS for Adolescent Depression

TypeinterventionalSponsorMayo ClinicRan2018 to 2023Enrolled47ConditionsMajor Depressive DisorderArmsNeuroStar TMS Therapy® System, NeuroStar XPLOR®
NCT03845504 naterminatednot on this mapstarted 2018, after this paper: background citation

Evaluating the Efficacy and Tolerability of Targeted Transcranial Magnetic Stimulation in Youth

TypeinterventionalSponsorStanford UniversityRan2018 to 2019Enrolled4ConditionsDepressionArmsIntermittent Theta Burst Stimulation
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  7. Left prefrontal transcranial magnetic stimulation for treatment-resistant depression in adolescents: a double-blind, randomized, sham-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Christopher A Wall1 PrairieCare Medical Group , Rochester, Minnesota.
Paul E Croarkin2 Department of Psychiatry and Psychology, Mayo Clinic , Rochester, Minnesota.
Mandie J Maroney-Smith3 Department of Radiology, Mayo Clinic , Rochester, Minnesota.
Laura M Haugen4 Department of Neurosurgery, Mayo Clinic , Rochester, Minnesota.
Joshua M Baruth5 University of Louisville School of Medicine, Louisville, Kentucky.
Mark A Frye2 Department of Psychiatry and Psychology, Mayo Clinic , Rochester, Minnesota.
Shirlene M Sampson2 Department of Psychiatry and Psychology, Mayo Clinic , Rochester, Minnesota.
John D Port2 Department of Psychiatry and Psychology, Mayo Clinic , Rochester, Minnesota.
Mayo Clinic · USUniversity of Louisville · US

Funding

Glutamate Probes in Adolescent DepressionK23MH100266 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2014 to 2017
$685k
NIMH NIH HHS K23 MH100266
6 · The paper itself

Abstract

objectivePreliminary studies suggest that repetitive transcranial magnetic stimulation (rTMS) may be an effective and tolerable intervention for adolescents with treatment-resistant depression. There is limited rationale to inform coil placement for rTMS dosing in this population. We sought to examine and compare three localization techniques for coil placement in the context of an open-label trial of high-frequency rTMS for adolescents with treatment-resistant depression.

methodsTen adolescents with treatment-resistant depression were enrolled in an open-label trial of high-frequency rTMS. Participants were offered 30 rTMS sessions (10 Hz, 120% motor threshold, left 3000 pulses applied to the dorsolateral prefrontal cortex) over 6-8 weeks. Coil placement for treatment was MRI guided. The scalp location for treatment was compared with the locations identified with standard 5 cm rule and Beam F3 methods.

resultsSeven adolescents completed 30 rTMS sessions. No safety or tolerability concerns were identified. Depression severity as assessed with the Children's Depression Rating Scale Revised improved from baseline to treatment 10, treatment 20, and treatment 30. Gains in depressive symptom improvement were maintained at 6 month follow-up visits. An MRI-guided approach for coil localization was feasible and efficient. Our results suggest that the 5 cm rule, Beam F3, and the MRI-guided localization approaches provided variable scalp targets for rTMS treatment.

conclusionsOpen-label, high-frequency rTMS was feasible, tolerable, and effective for adolescents with treatment-resistant depression. Larger, blinded, sham-controlled trials are needed for definitive safety and efficacy data. Further efforts to understand optimal delivery, dosing, and biomarker development for rTMS treatments of adolescent depression are warranted.

Indexed as

AdolescentDepressive Disorder, Treatment-ResistantFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMajor Depressive DisorderMalePrefrontal CortexPsychiatric Status Rating ScalesSeverity of Illness IndexTranscranial Magnetic StimulationTreatment Outcome

Identifiers

PMID26849202
PMCPMC5035831
OpenAlexW2268773565

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.