Evidence map›Paper›PMID 26857178›Full record

ArticleTrends in microbiology2016

Preventing Congenital Cytomegalovirus Infection: Protection to a 'T'.

Mark R Schleiss

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Impact of maternal nutrition in viral infections during pregnancy.Biochimica et biophysica acta. Molecular basis of disease · 2021
    Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mark R SchleissCenter for Infectious Diseases and Microbiology Translational Research, Division of Pediatric Infectious Diseases and Immunology, University of Minnesota Medical School, 2001 6(th) Street SE, Minneapolis, MN 55455, USA. Electronic address: schleiss@umn.edu.
University of Minnesota Medical Center · US

Funding

Viral Immunomodulation and Rational CMV Vaccine DesignR01HD044864 · NICHD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GEBALLE, ADAM P., MCVOY, MICHAEL A · 2003 to 2015
$4.5M
Optimized Vaccines Against Congenital Infection and Maternal Reinfection with CMVR01HD079918 · NICHD · UNIVERSITY OF MINNESOTA · PI SCHLEISS, MARK R. · 2015 to 2019
$1.6M
Preclinical Evaluation of a Novel rLCMV Single-Cycle Vectored CMV VaccineR56AI114013 · NIAID · UNIVERSITY OF MINNESOTA · PI SCHLEISS, MARK R. · 2015 to 2015
$342k
ELISPOT Peptide Mapping Assay to Identify Novel Candidate CMV Vaccine AntigensR03HD082273 · NICHD · UNIVERSITY OF MINNESOTA · PI SCHLEISS, MARK R. · 2015 to 2016
$151k
NIAID NIH HHS AI114013NIAID NIH HHS R56 AI114013NICHD NIH HHS HD044864NICHD NIH HHS HD079918NICHD NIH HHS HD082273NICHD NIH HHS R01 HD079918
6 · The paper itself

Abstract

A lack of knowledge about the correlates of maternal immunity required for protection of the placenta and fetus against congenital cytomegalovirus (CMV) transmission has complicated vaccine development. New work from Bialas and colleagues demonstrates a critical role for maternal CD4(+) T cells in controlling viremia and preventing CMV-associated fetal disease.

Indexed as

Infectious Disease Transmission, VerticalMaternal-Fetal ExchangeAnimalsCD4-Positive T-LymphocytesCytomegalovirus InfectionsFemalePregnancyanimal modelscongenital cytomegalovirus infectioncytomegalovirus immunitycytomegalovirus vaccinepentameric complexplacenta

Identifiers

PMID26857178
PMCPMC4836615
OpenAlexW2254670929

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.