Evidence map›Paper›PMID 26865341›Full record

ReviewAnnual review of plant biology2016

The Conservation and Function of RNA Secondary Structure in Plants.

Lee E Vandivier, Stephen J Anderson, Shawn W Foley, Brian D Gregory

Abstract readReview
In one paragraph

Review in Annual review of plant biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Modified RNAs and predictions with the ViennaRNA Package.Bioinformatics (Oxford, England) · 2023
    Article
  16. A positive feedback circuit between RN7SK snRNA and mMolecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  17. Sulfonylation of RNA 2'-OH groups.ACS central science · 2023
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lee E VandivierDepartment of Biology, School of Arts and Sciences, and.
Stephen J AndersonDepartment of Biology, School of Arts and Sciences, and.
Shawn W FoleyDepartment of Biology, School of Arts and Sciences, and.
Brian D GregoryDepartment of Biology, School of Arts and Sciences, and.
University of Pennsylvania · US

Funding

TRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
VANADIUM INTERACTION STUDIES IN RELATION TO THE INHIBITION OF NA+-K+-ATPASES06GM008216 · NIGMS · UNIVERSITY OF PUERTO RICO AT HUMACAO · PI ALEGRIA, ANTONIO E · 1989 to 2010
$8.0M
NIGMS NIH HHS S06 GM008216NIGMS NIH HHS T32 GM007229NIGMS NIH HHS T32 GM008216
6 · The paper itself

Abstract

RNA transcripts fold into secondary structures via intricate patterns of base pairing. These secondary structures impart catalytic, ligand binding, and scaffolding functions to a wide array of RNAs, forming a critical node of biological regulation. Among their many functions, RNA structural elements modulate epigenetic marks, alter mRNA stability and translation, regulate alternative splicing, transduce signals, and scaffold large macromolecular complexes. Thus, the study of RNA secondary structure is critical to understanding the function and regulation of RNA transcripts. Here, we review the origins, form, and function of RNA secondary structure, focusing on plants. We then provide an overview of methods for probing secondary structure, from physical methods such as X-ray crystallography and nuclear magnetic resonance (NMR) imaging to chemical and nuclease probing methods. Combining these latter methods with high-throughput sequencing has enabled them to scale across whole transcriptomes, yielding tremendous new insights into the form and function of RNA secondary structure.

Indexed as

Gene Expression Regulation, PlantNucleic Acid ConformationRNA, MessengerRNA, PlantPlantsTranscriptomeRNA, MessengerRNA, Planthigh-throughput sequencingmicroRNAsposttranscriptional regulationRNA-binding proteinsRNA secondary structuresmall interfering RNAs

Identifiers

PMID26865341
PMCPMC5125251
OpenAlexW2153866367

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.