ArticleToxicological sciences : an official journal of the Society of Toxicology2016
Tungsten Promotes Sex-Specific Adipogenesis in the Bone by Altering Differentiation of Bone Marrow-Resident Mesenchymal Stromal Cells.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Osteogenic potential of nanostructured Cu/W/Co in Fe-Mn alloys designed for maxillofacial applications: in vivo study in dog model.Journal of materials science. Materials in medicine · 2025Article
- Tungsten toxicity and carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023Article
- Neuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Multipollutant, longitudinal analysis of the association between urinary tungsten and incident diabetes in a rural population.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Inhalation of Tungsten Metal Particulates Alters the Lung and Bone Microenvironments Following Acute Exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Tungsten Increases Sex-Specific Osteoclast Differentiation in Murine Bone.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Association of Urinary and Blood Concentrations of Heavy Metals with Measures of Bone Mineral Density Loss: a Data Mining Approach with the Results from the National Health and Nutrition Examination Survey.Biological trace element research · 2021Article
- Study of accumulation behaviour of tungsten based composite using electron probe micro analyser for the application in bone tissue engineering.Saudi journal of biological sciences · 2020Article
- Effects of demographic factors on adipogenic and chondrogenic differentiation in bone marrow-derived stem cells.Experimental and therapeutic medicine · 2019Article
- Environmental Factors Impacting Bone-Relevant Chemokines.Frontiers in endocrinology · 2017Article
- Tungsten: an Emerging Toxicant, Alone or in Combination.Current environmental health reports · 2016Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
Abstract
Tungsten is a naturally occurring metal that increasingly is being incorporated into industrial goods and medical devices, and is recognized as an emerging contaminant. Tungsten preferentially and rapidly accumulates in murine bone in a concentration-dependent manner; however the effect of tungsten deposition on bone biology is unknown. Other metals alter bone homeostasis by targeting bone marrow-derived mesenchymal stromal cell (MSC) differentiation, thus, we investigated the effects of tungsten on MSCsin vitroandin vivoIn vitro, tungsten shifted the balance of MSC differentiation by enhancing rosiglitazone-induced adipogenesis, which correlated with an increase in adipocyte content in the bone of tungsten-exposed, young, male mice. Conversely, tungsten inhibited osteogenesis of MSCsin vitro; however, we found no evidence that tungsten inhibited osteogenesisin vivo Interestingly, two factors known to influence adipogenesis are sex and age of mice. Both female and older mice have enhanced adipogenesis. We extended our study and exposed young female and adult (9-month) male and female mice to tungsten for 4 weeks. Although tungsten accumulated to a similar extent in young female mice, it did not promote adipogenesis. Interestingly, tungsten did not accumulate in the bone of older mice; it was undetectable in adult male mice, and just above the limit of detect in adult female mice. Surprisingly, tungsten enhanced adipogenesis in adult female mice. In summary, we found that tungsten alters bone homeostasis by altering differentiation of MSCs, which could have significant implications for bone quality, but is highly dependent upon sex and age.
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