ReviewEuropean heart journal2016
Disordered haematopoiesis and athero-thrombosis.
Review in European heart journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 106 citations in OpenAlex.
- Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial.EBioMedicine · 2021Trial
- The role of vascular aging, bone marrow and immune system in hypertension.Cell death discovery · 2026Review
- Association of neutrophil-to-prognostic nutritional index ratio with long-term mortality in acute myocardial infarction from Chinese and US cohorts.Frontiers in nutrition · 2026Article
- Inflammation and the Heart: The Role of Traditional Factors.Cardiology research and practice · 2026Review
- Imbalances in circulating monocyte and high-density lipoprotein cholesterol exacerbates the residual risk of incident myocardial infarction beyond LDL-C: a real-life, prospective cohort study.Journal of translational medicine · 2025Article
- A Biomimetic Macrophage-Membrane-Fused Liposomal System Loaded with GVs-HV Recombinant Plasmid for Targeted Anti-Atherosclerosis Therapy.Pharmaceutics · 2025Article
- Prognostic value of systemic immune-Inflammatory index in patients with diabetes mellitus and acute coronary syndrome after percutaneous coronary intervention: a prospective cohort study.BMC cardiovascular disorders · 2025Article
- The gut microbiota-bile acid-TGR5 axis orchestrates platelet activation and atherothrombosis.Nature cardiovascular research · 2025Article
- Intermittent fasting inhibits platelet activation and thrombosis through the intestinal metabolite indole-3-propionate.Life metabolism · 2025Article
- Improved MRI detection of inflammation-induced changes in bone marrow microstructure in mice: a machine learning-enhanced T2 distribution analysis.European radiology experimental · 2025Article
- Immunometabolism in atherosclerotic disorders.Nature cardiovascular research · 2024Review
- Prognostic implications of systemic immune-inflammation index in myocardial infarction patients with and without diabetes: insights from the NOAFCAMI-SH registry.Cardiovascular diabetology · 2024Article
- Haematological Indices in Acute Coronary Syndrome Patients in Ethiopia: A Comparative Cross-Sectional Study.Journal of blood medicine · 2024Article
- New Insights into the Role of HMGB2 in ST-Segment Elevation Myocardial Infarction.International journal of general medicine · 2023Article
- Role of reactive oxygen species in regulating 27-hydroxycholesterol-induced apoptosis of hematopoietic progenitor cells and myeloid cell lines.Cell death & disease · 2022Article
- The Role of Inflammation in Cardiovascular Disease.International journal of molecular sciences · 2022Review
- Impaired Hematopoietic Stem/Progenitor Cell Traffic and Multi-organ Damage in Diabetes.Stem cells (Dayton, Ohio) · 2022Article
- Synergism between obesity and HFpEF on neutrophils phenotype and its regulation by adipose tissue-molecules and SGLT2i dapagliflozin.Journal of cellular and molecular medicine · 2022Article
- Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities.Periodontology 2000 · 2022Review
- Oxidative Stress in Neutrophils: Implications for Diabetic Cardiovascular Complications.Antioxidants & redox signaling · 2022Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Atherosclerosis, the major underlying cause of cardiovascular disease, is characterized by a lipid-driven infiltration of inflammatory cells in large and medium arteries. Increased production and activation of monocytes, neutrophils, and platelets, driven by hypercholesterolaemia and defective high-density lipoproteins-mediated cholesterol efflux, tissue necrosis and cytokine production after myocardial infarction, or metabolic abnormalities associated with diabetes, contribute to atherogenesis and athero-thrombosis. This suggests that in addition to traditional approaches of low-density lipoproteins lowering and anti-platelet drugs, therapies directed at abnormal haematopoiesis, including anti-inflammatory agents, drugs that suppress myelopoiesis, and excessive platelet production, rHDL infusions and anti-obesity and anti-diabetic agents, may help to prevent athero-thrombosis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.