Trial reportJournal of diabetes science and technology2016
Hybrid Closed-Loop Insulin Delivery in Type 1 Diabetes During Supervised Outpatient Conditions.
Trial report in Journal of diabetes science and technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Optimizing Hybrid Closed-Loop Therapy in Adolescents and Emerging Adults Using the MiniMed 670G System.Diabetes care · 2018Trial
- Double Dummy Design for Blinding Studies With Automated Insulin Delivery Systems: A Proof of Concept Trial.Journal of diabetes science and technology · 2026Article
- Patient reported outcome measures in children and adolescents with type 1 diabetes using advanced hybrid closed loop insulin delivery.Frontiers in endocrinology · 2022Article
- Hybrid Close-Loop Systems Versus Predictive Low-Glucose Suspend and Sensor-Augmented Pump Therapy in Patients With Type 1 Diabetes: A Single-Center Cohort Study.Frontiers in endocrinology · 2022Article
- Intelligent automated drug administration and therapy: future of healthcare.Drug delivery and translational research · 2021Review
- Performance Analysis of Different Embedded Systems and Open-Source Optimization Packages Towards an Impulsive MPC Artificial Pancreas.Frontiers in endocrinology · 2021Article
- Determining the Perception and Willingness of Primary Care Providers to Prescribe Advanced Diabetes Technologies.Journal of patient-centered research and reviews · 2021Article
- Six months of hybrid closed loop in the real-world: An evaluation of children and young adults using the 670G system.Pediatric diabetes · 2020Observational
- Real world hybrid closed-loop discontinuation: Predictors and perceptions of youth discontinuing the 670G system in the first 6 months.Pediatric diabetes · 2020Observational
- Realizing a Closed-Loop (Artificial Pancreas) System for the Treatment of Type 1 Diabetes.Endocrine reviews · 2019Review
- Adding wisdom to 'smart' bioelectronic systems: a design framework for physiologic control including practical examples.Bioelectronics in medicine · 2019Article
- Effect of 6 months of hybrid closed-loop insulin delivery in adults with type 1 diabetes: a randomised controlled trial protocol.BMJ open · 2018Article
- Event-Triggered Model Predictive Control for Embedded Artificial Pancreas Systems.IEEE transactions on bio-medical engineering · 2018Article
- Continuous Glucose Monitoring: A Review of Recent Studies Demonstrating Improved Glycemic Outcomes.Diabetes technology & therapeutics · 2017Review
- Stepwise Approach to Problematic Hypoglycemia in Korea: Educational, Technological, and Transplant Interventions.Endocrinology and metabolism (Seoul, Korea) · 2017Review
- A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017Review
- Glucose Outcomes with the In-Home Use of a Hybrid Closed-Loop Insulin Delivery System in Adolescents and Adults with Type 1 Diabetes.Diabetes technology & therapeutics · 2017Article
- Coming of age: the artificial pancreas for type 1 diabetes.Diabetologia · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEfficacy and safety of the Medtronic Hybrid Closed-Loop (HCL) system were tested in subjects with type 1 diabetes in a supervised outpatient setting.
methodsThe HCL system is a prototype research platform that includes a sensor-augmented insulin pump in communication with a control algorithm housed on an Android-based cellular device. Nine subjects with type 1 diabetes (5 female, mean age 53.3 years, mean A1C 7.2%) underwent 9 studies totaling 571 hours of closed-loop control using either default or personalized parameters. The system required meal announcements with estimates of carbohydrate (CHO) intake that were based on metabolic kitchen quantification (MK), dietician estimates (D), or subject estimates (Control). Postprandial glycemia was compared for MK, D, and Control meals.
resultsThe overall sensor glucose mean was 145 ± 43, the overall percentage time in the range 70-180 mg/dL was 80%, the overall percentage time <70 mg/dL was 0.79%. Compared to intervals of default parameter use (225 hours), intervals of personalized parameter use (346 hours), sensor glucose mean was 158 ± 49 and 137 ± 37 mg/dL (P < .001), respectively, and included more time in range (87% vs 68%) and less time below range (0.54% vs 1.18%). Most subjects underestimated the CHO content of meals, but postprandial glycemia was not significantly different between MK and matched Control meals (P = .16) or between D and matched Control meals (P = .76). There were no episodes of severe hypoglycemia.
conclusionsThe HCL system was efficacious and safe during this study. Personally adapted HCL parameters were associated with more time in range and less time below range than default parameters. Accurate estimates of meal CHO did not contribute to improved postprandial glycemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.